Q8CAE2
Gene name |
Henmt1 |
Protein name |
Small RNA 2'-O-methyltransferase |
Names |
HEN1 methyltransferase homolog 1, mHEN1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66715 |
EC number |
2.1.1.386: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CAE2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CAE2-F1 | Predicted | AlphaFoldDB |
29 variants for Q8CAE2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs216553513 | 6 | S>N | No | EVA | |
| rs1133310787 | 8 | P>L | No | EVA | |
| rs108860490 | 21 | S>C | No | EVA | |
| rs3388664097 | 27 | R>W | No | EVA | |
| rs108003046 | 42 | D>E | No | EVA | |
| rs3388660303 | 52 | V>L | No | EVA | |
| rs3388660322 | 98 | E>K | No | EVA | |
| rs3388654811 | 111 | L>S | No | EVA | |
| rs3388656667 | 127 | D>E | No | EVA | |
| rs3388640573 | 146 | F>I | No | EVA | |
| rs3388658095 | 171 | L>P | No | EVA | |
| rs3388656678 | 175 | V>L | No | EVA | |
| rs3388654825 | 194 | W>* | No | EVA | |
| rs260122984 | 196 | L>S | No | EVA | |
| rs3388656673 | 216 | A>V | No | EVA | |
| rs3393521992 | 241 | S>* | No | EVA | |
| rs3393575173 | 241 | S>T | No | EVA | |
| rs3393477866 | 243 | S>* | No | EVA | |
| rs3388658121 | 246 | C>S | No | EVA | |
| rs3388647325 | 247 | D>V | No | EVA | |
| rs254813621 | 250 | V>I | No | EVA | |
| rs3388653418 | 287 | Y>N | No | EVA | |
| rs252012497 | 298 | R>G | No | EVA | |
| rs213659565 | 305 | M>T | No | EVA | |
| rs3388651907 | 317 | A>S | No | EVA | |
| rs3388656690 | 317 | A>V | No | EVA | |
| rs3388664149 | 364 | R>P | No | EVA | |
| rs3388662267 | 370 | S>* | No | EVA | |
| rs224363513 | 394 | E>D | No | EVA |
No associated diseases with Q8CAE2
No regional properties for Q8CAE2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8CAE2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.386 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P granule | A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| O-methyltransferase activity | Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
| small RNA 2'-O-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| piRNA metabolic process | The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
| RNA methylation | Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. |
| siRNA processing | A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMAESIPCN | SVVGGNFKEV | SPEKVIRFKP | PLYKQRYQFV | RDLVDRHEPK | KVADLGCGDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLLKLLKIYP | CIQLLVGVDI | NEEKLHSNGH | RLSPYLGEFV | KPRDLDLTVT | LYHGSVVERD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRLLGFDLIT | CIELIEHLDS | DDLARFPDVV | FGYLSPAMVV | ISTPNAEFNP | LFPTVTLRDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DHKFEWSRME | FQTWALHVAN | CYNYRVEFTG | VGTPPAGSEH | VGYCTQIGVF | TKNGGKLSKP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVSQQCDQHV | YKPVYTTSYP | SLQQEKVLKF | VLVGELLIQV | DRLRLRYQRM | LRDREKDRGP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPGDMDSCPA | PHLLLGAVFT | EAEKARIESS | PKPFCEGEKF | YIPLQRLLTY | PKLHRLCADE |
| 370 | 380 | 390 | |||
| DRVRSLIADS | VCLSSDGSAV | VVDLHNSWDY | RPEEN |