Q8C9E8

PR
Gene name
Calhm6 (Fam26f)
Protein name
Calcium homeostasis modulator protein 6
Names
Protein FAM26F
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:215900
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

249-313 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C9E8

Entry ID Method Resolution Chain Position Source
AF-Q8C9E8-F1 Predicted AlphaFoldDB

24 variants for Q8C9E8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389104673 5 K>M No EVA
rs3389081714 11 Q>R No EVA
rs255143008 12 R>K No EVA
rs247311991 14 H>Y No EVA
rs3401042251 30 G>E No EVA
rs3400688317 36 S>P No EVA
rs3389097399 112 W>* No EVA
rs3389104706 136 Y>N No EVA
rs233086658 156 K>E No EVA
rs217458095 156 K>M No EVA
rs3389097216 164 I>N No EVA
rs1134918002 181 A>S No EVA
rs3389094925 187 L>I No EVA
rs3389094617 213 E>D No EVA
rs3389069039 221 N>I No EVA
rs231814280 232 E>K No EVA
rs36704885 240 E>G No EVA
rs3389039465 269 Q>R No EVA
rs36411729 281 E>K No EVA
rs3389094847 285 G>C No EVA
rs3389094433 285 G>D No EVA
rs218951948 288 R>C No EVA
rs3389099490 290 V>A No EVA
rs3389094868 292 G>* No EVA

No associated diseases with Q8C9E8

3 regional properties for Q8C9E8

Type Name Position InterPro Accession
conserved_site GHMP kinase, ATP-binding, conserved site 87 - 98 IPR006203
domain GHMP kinase N-terminal domain 80 - 141 IPR006204
domain GHMP kinase, C-terminal domain 202 - 280 IPR013750

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Recruited at immune synapses in response to pathogen-derived and proinflammatory stimuli
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
cation channel activity Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKFKAVLDL QRKHRNALGY SLVTLLTAGG EKIFSSVVFQ CPCTATWNLP YGLVFLLVPA
70 80 90 100 110 120
LALFLLGYAL SARTWRLLTG CCSRSARFSS GLRSAFVCAQ LSMTAAFAPL TWVAVALLEG
130 140 150 160 170 180
SFYQCAVSGS ARLAPYLCKG RDPNCNATLP QAPCNKQKVE MQEILSQLKA QSQVFGWILI
190 200 210 220 230 240
AAVIILLLLV KSVTRCFSPV SYLQLKFWEI YWEKEKQILQ NQAAENATQL AEENVRCFFE
250 260 270 280 290 300
CSKPKECNTP SSKDWQEISA LYTFNPKNQF YSMLHKYVSR EEMSGSVRSV EGDAVIPALG
310
FVDDMSMTNT HEL