Q8C9A2

PR
Gene name
Endov
Protein name
Endonuclease V
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:338371
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

223-338 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for Q8C9A2

Entry ID Method Resolution Chain Position Source
5AOY X-ray 175 A A 1-250 PDB
6OZJ X-ray 225 A A/B 1-253 PDB
6OZK X-ray 210 A A/B 6-250 PDB
6OZL X-ray 210 A A/B 1-253 PDB
6OZM X-ray 215 A A/B 1-253 PDB
6OZN X-ray 190 A A/B 1-253 PDB
6OZO X-ray 223 A A/B 1-253 PDB
6OZP X-ray 196 A A/B 8-252 PDB
6OZQ X-ray 215 A A/B 1-253 PDB
6OZR X-ray 215 A A/B 1-253 PDB
6OZS X-ray 241 A A/B 6-252 PDB
AF-Q8C9A2-F1 Predicted AlphaFoldDB

13 variants for Q8C9A2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3402883291 7 E>Q No EVA
rs3402461812 48 V>F No EVA
rs3402944989 69 V>L No EVA
rs3389158149 95 F>I No EVA
rs27015014 225 H>Y No EVA
rs3389227762 237 R>C No EVA
rs3389224352 260 Q>* No EVA
rs252827557 275 P>L No EVA
rs27015001 291 C>F No EVA
rs29439076 300 R>P No EVA
rs3389221763 307 F>I No EVA
rs3389238611 320 H>L No EVA
rs230354277 337 P>L No EVA

No associated diseases with Q8C9A2

1 regional properties for Q8C9A2

Type Name Position InterPro Accession
domain AP2/ERF domain 106 - 170 IPR001471

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Cytoplasm, Stress granule
  • Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

5 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
endodeoxyribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
endoribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
magnesium ion binding Binding to a magnesium (Mg) ion.
single-stranded RNA binding Binding to single-stranded RNA.

1 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N8Q3 ENDOV Endonuclease V Homo sapiens (Human) PR
10 20 30 40 50 60
MAHTAAERPP EETLSLWKGE QARLKARVVD RDTEAWQRDP SFSGLQKVGG VDVSFVKGDS
70 80 90 100 110 120
VRACASLVVL SYPELKVVYE DSRMVGLKAP YVSGFLAFRE VPFLVELVQR LQEKEPDLMP
130 140 150 160 170 180
QVVLVDGNGV LHQRGFGVAC HLGVLTELPC IGVAKKLLQV DGLENNALHK EKIVLLQAGG
190 200 210 220 230 240
DTFPLIGSSG TVLGMALRSH DHSTKPLYVS VGHRISLEVA VRLTHHCCRF RIPEPIRQAD
250 260 270 280 290 300
IRSREYIRRT LGQLGVAPAQ RKDRSQKEQR PNACPQGGPG ALADQGRPPE CDGRDSSSDR
310 320 330
KAPEPGFQEQ KDQQLEGTGH QEDSDLWPPS PAWVQSPP