Q8C7U1

PR
Gene name
N4bp3
Protein name
NEDD4-binding protein 3
Names
N4BP3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:212706
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-537 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C7U1

Entry ID Method Resolution Chain Position Source
AF-Q8C7U1-F1 Predicted AlphaFoldDB

21 variants for Q8C7U1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389130440 34 A>V No EVA
rs3389118257 61 L>I No EVA
rs3389157405 71 R>L No EVA
rs3402202159 134 K>R No EVA
rs3389094655 202 F>S No EVA
rs3389125719 203 S>R No EVA
rs3402105125 221 R>G No EVA
rs3389150655 232 L>Q No EVA
rs3389166573 290 L>V No EVA
rs3389125721 306 E>G No EVA
rs3389161926 307 R>H No EVA
rs260784496 341 R>Q No EVA
rs221106515 343 S>F No EVA
rs3389156481 345 S>T No EVA
rs3389143215 408 Q>H No EVA
rs3389130455 410 A>T No EVA
rs3389094729 411 E>K No EVA
rs3389125723 455 R>I No EVA
rs3389130452 488 E>* No EVA
rs3389143237 490 K>E No EVA
rs3389155225 523 E>D No EVA

No associated diseases with Q8C7U1

No regional properties for Q8C7U1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8C7U1

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle
  • Cell projection, axon
  • Cell projection, dendrite
  • In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15049 N4BP3 NEDD4-binding protein 3 Homo sapiens (Human) PR
Q3LUD3 N4bp3 Nedd4 binding protein 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MATTSGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL GQREFFSYLH
70 80 90 100 110 120
LPKKDGKTTK RAPRNEPDYA TLYYREHPRA GDFSKTSLPE RGRFDKCRIR PSVFKPPVGS
130 140 150 160 170 180
GKGFLSMQSL AAHKGQKLWR SNGSLHTLAC HPPLSPGPRA SQARAQLLHA LSLDEGGPEP
190 200 210 220 230 240
SLSDSSSGGS FGRSPGTGPS PFSSSLGHIN HLGGSLDRAP RSPKESGPLA VLSCLPEPPP
250 260 270 280 290 300
PYEFSCPTTE EVAVLPEARE ELKRDLGDQD VSNSFTQVLE ERQRLWLSEL KRLYVERLHE
310 320 330 340 350 360
VAQKAERSER NLQLQLFMAQ QEQRRLRKEL RAQQGLAPEP RTSGSSMEAD PNARPEEEAR
370 380 390 400 410 420
WEVCQKTAEI SLLKQQLREA QAELAQKLAE IFSLKTQLRG SRAQAQAQDA ELARLREAVH
430 440 450 460 470 480
SLQEQAPREE APGSCETDDC KSRGLLGEAG GSEAREGAEQ LRAELLQERL RGQEQALRFE
490 500 510 520 530
QERQTWQEEK ERVLRYQREI QGSYMDMYRR NQALEHELRL LREPPTSWSP RLESSKI