Q8C7E7
Gene name |
Stbd1 |
Protein name |
Starch-binding domain-containing protein 1 |
Names |
Genethonin-1, Glycophagy cargo receptor stbd1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:52331 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C7E7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C7E7-F1 | Predicted | AlphaFoldDB |
19 variants for Q8C7E7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388770005 | 32 | K>N | No | EVA | |
| rs3388760412 | 40 | Q>H | No | EVA | |
| rs3388760359 | 48 | A>V | No | EVA | |
| rs239255433 | 51 | P>R | No | EVA | |
| rs3396001326 | 75 | K>* | No | EVA | |
| rs3388756177 | 126 | S>P | No | EVA | |
| rs3388760408 | 128 | A>P | No | EVA | |
| rs3388763365 | 129 | D>H | No | EVA | |
| rs3388776610 | 154 | A>S | No | EVA | |
| rs243571950 | 163 | A>T | No | EVA | |
| rs3388769792 | 166 | P>H | No | EVA | |
| rs3388770054 | 204 | G>A | No | EVA | |
| rs3388753944 | 232 | V>L | No | EVA | |
| rs3388771994 | 251 | H>Y | No | EVA | |
| rs3388769865 | 286 | L>R | No | EVA | |
| rs3388756126 | 292 | F>Y | No | EVA | |
| rs3395516867 | 322 | L>P | No | EVA | |
| rs3388772345 | 325 | G>C | No | EVA | |
| rs3395721027 | 335 | W>G | No | EVA |
No associated diseases with Q8C7E7
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| phagophore assembly site membrane | A cellular membrane associated with the phagophore assembly site. |
| T-tubule | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| cargo receptor activity | Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| glycogen binding | Binding to glycogen. |
| polysaccharide binding | Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
| starch binding | Binding to starch. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| glycogen catabolic process | The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
| glycophagy | The selective autophagy process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions. |
| intracellular transport | The directed movement of substances within a cell. |
| substrate localization to autophagosome | The localization process by which an autophagic substrate is delivered to a forming autophagosome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGAVWSALLV | GGGLAGALIL | WLLRGDSGAP | GKDGVAEPPQ | KGAPPGEAAA | PGDGPGGGGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGLSPEPSDR | ELVSKAEHLR | ESNGHLISES | KDLGNLPEAQ | RLQNVGADWV | NAREFVPVGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IPDTHSRADS | EAARNQSPGS | HGGEWRLPKG | QETAVKVAGS | VAAKLPSSSL | LVDRAKAVSQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DQAGHEDWEV | VSRHSSWGSV | GLGGSLEASR | LSLNQRMDDS | TNSLVGGRGW | EVDGKVASLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PQQVSIQFQV | HYTTNTDVQF | IAVTGDHESL | GRWNTYIPLH | YCKDGLWSHS | VFLPADTVVE |
| 310 | 320 | 330 | |||
| WKFVLVENKE | VTRWEECSNR | FLQTGHEDKV | VHGWWGIH |