Q8C796
Gene name |
Rcor2 |
Protein name |
REST corepressor 2 |
Names |
M-CoREST |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:104383 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C796
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C796-F1 | Predicted | AlphaFoldDB |
19 variants for Q8C796
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389524065 | 64 | P>L | No | EVA | |
| rs3389534495 | 79 | S>F | No | EVA | |
| rs3408830530 | 137 | V>E | No | EVA | |
| rs3389517470 | 191 | R>K | No | EVA | |
| rs3389515822 | 227 | L>P | No | EVA | |
| rs213820329 | 245 | I>M | No | EVA | |
| rs3408916582 | 292 | I>L | No | EVA | |
| rs3389517330 | 306 | S>I | No | EVA | |
| rs3389532773 | 325 | N>I | No | EVA | |
| rs3389489767 | 352 | G>R | No | EVA | |
| rs3389431180 | 354 | I>V | No | EVA | |
| rs3389524045 | 437 | P>L | No | EVA | |
| rs3389470420 | 444 | T>I | No | EVA | |
| rs3408916544 | 444 | T>P | No | EVA | |
| rs3389479327 | 448 | Q>H | No | EVA | |
| rs3389522101 | 449 | P>S | No | EVA | |
| rs3389532730 | 477 | Q>E | No | EVA | |
| rs3389470482 | 492 | P>H | No | EVA | |
| rs3389470457 | 499 | H>R | No | EVA |
No associated diseases with Q8C796
5 regional properties for Q8C796
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ELM2 domain | 44 - 129 | IPR000949 |
| domain | SANT/Myb domain | 131 - 179 | IPR001005-1 |
| domain | SANT/Myb domain | 328 - 376 | IPR001005-2 |
| domain | SANT domain | 130 - 181 | IPR017884-1 |
| domain | SANT domain | 327 - 378 | IPR017884-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| histone deacetylase complex | A protein complex that possesses histone deacetylase activity. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| histone deacetylation | The modification of histones by removal of acetyl groups. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IZ40 | RCOR2 | REST corepressor 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSVMEKPSA | GSGILSRSRA | KTAPNGGQPH | SEDDSSEEEH | SHDSMIRVGT | NYQAVIPECK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PESPARYSNK | ELKGMLVWSP | NHCVSDAKLD | KYIAMAKEKH | GYNIEQALGM | LLWHKHDVEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLADLANFTP | FPDEWTVEDK | VLFEQAFGFH | GKCFQRIQQM | LPDKVIPSLV | KYYYSWKKTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRTSVMDRQA | RRLGGRKDKE | DSDELEEGRG | AVSEGEPDTG | DPKREPLPSR | PLNARPGPGK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEVQISQYRH | HPLRTRRRPP | KGMYLSPEGL | TAVSGSPDLA | NLTLRGLDSQ | LISLKRQVQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MKQTNSSLRQ | ALEGGIDPLR | PPEANTKFNS | RWTTDEQLLA | VQAIRRYGKD | FGAIAEVIGN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KTLTQVKTFF | VSYRRRFNLE | EVLQEWEAEQ | DGAPAAPVPT | EEARRGAPVP | ATALEEDDEV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QITSVSTSVP | RSVPPAPPPP | PPPTSLSQPP | PLLRPPLPTA | PTLLRQPPPL | QQGRFLQPRL |
| 490 | 500 | 510 | 520 | ||
| APNQPPPPLI | RPALAASRHS | ARPGPQPPPT | LVGAPLEPPA | PSL |