Q8C561

PR
Gene name
Lmbrd2
Protein name
G-protein coupled receptor-associated protein LMBRD2
Names
LMBR1 domain-containing protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:320506
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

44-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C561

Entry ID Method Resolution Chain Position Source
AF-Q8C561-F1 Predicted AlphaFoldDB

18 variants for Q8C561

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3405956829 37 G>D No EVA
rs3389350433 42 W>G No EVA
rs48579997 43 Y>C No EVA
rs1132981840 97 K>N No EVA
rs1135022204 98 P>L No EVA
rs3389315971 106 I>N No EVA
rs3389323549 206 L>F No EVA
rs3389350386 223 L>R No EVA
rs3405882772 332 E>* No EVA
rs3389364098 346 S>T No EVA
rs3389354974 351 F>C No EVA
rs3389364107 353 H>N No EVA
rs3405515984 376 Y>S No EVA
rs3389354988 393 L>F No EVA
rs3389364108 404 E>D No EVA
rs3389368309 404 E>G No EVA
rs3389348063 469 T>N No EVA
rs3389355053 609 D>N No EVA

No associated diseases with Q8C561

No regional properties for Q8C561

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8C561

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
adrenergic receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8MRQ4 CG8135 LMBR1 domain-containing protein 2 homolog Drosophila melanogaster (Fruit fly) PR
Q68DH5 LMBRD2 G-protein coupled receptor-associated protein LMBRD2 Homo sapiens (Human) PR
10 20 30 40 50 60
MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF ILPLDVSTTI
70 80 90 100 110 120
YNRCRHAAAN SSPPENTNVT GLDASVTPAP RQHPCFKPWS YIPDGIMPIF WRVVYWTSQF
130 140 150 160 170 180
LTWILLPFMQ SYARSGGFSI TGKIKTALIE NAIYYGTYLL IFGAFLIYVA VNPRLHLEWN
190 200 210 220 230 240
QLQTIGIAAA NTWGLFLLVL LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA
250 260 270 280 290 300
EENLEDVMEE VRKVNESIKY NHPLRKCVDT ILKKCPTDYQ EKMGRNMDDY EDFDEKRNTY
310 320 330 340 350 360
PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ FVHTFQSPEP
370 380 390 400 410 420
ENRFIQYFYN PTVEWYWECL LRPWFHRTLA VVLSIFSVIV VWSECTFFST TPVLSLFAVF
430 440 450 460 470 480
IQLAERTYNY IYIEIACFLS IFFLSICVYS TVFRIRVFNY YYLASHHQTD AYSLLFSGML
490 500 510 520 530 540
FCRLTPPLCL NFLGLTHMDS SISHQNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL
550 560 570 580 590 600
CIATYFSLGT RCLNLLGFQQ FMGDNDMTSD LVDEGKELIR REKRKRQRQE EGENRRREWK
610 620 630 640 650 660
ERYGHNREDS TRNRNVHPDP KESNFSDTTT NWSSKYTRAN NRTERDRIEL LQDAEPLDFN
670 680 690
AETFTDESLE PESGRYQPGG RYLSMSSSII FEDI