Q8C522
Gene name |
Endod1 (Kiaa0830) |
Protein name |
Endonuclease domain-containing 1 protein |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71946 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C522
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C522-F1 | Predicted | AlphaFoldDB |
22 variants for Q8C522
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs255588152 | 48 | A>V | No | EVA | |
| rs3389017637 | 73 | H>R | No | EVA | |
| rs3389027187 | 97 | L>P | No | EVA | |
| rs13472153 | 118 | L>V | No | EVA | |
| rs3389024602 | 121 | V>SDG* | No | EVA | |
| rs3388973050 | 122 | D>E | No | EVA | |
| rs3389021896 | 123 | N>D | No | EVA | |
| rs3389024582 | 145 | Y>H | No | EVA | |
| rs49169618 | 148 | P>H | No | EVA | |
| rs3389017634 | 185 | A>S | No | EVA | |
| rs3388973043 | 187 | I>N | No | EVA | |
| rs3389011311 | 213 | V>M | No | EVA | |
| rs3389022054 | 225 | C>G | No | EVA | |
| rs3389018781 | 280 | K>M | No | EVA | |
| rs261732570 | 282 | I>V | No | EVA | |
| rs245310110 | 285 | V>A | No | EVA | |
| rs222850965 | 316 | L>M | No | EVA | |
| rs240671487 | 413 | F>C | No | EVA | |
| rs3389004095 | 414 | L>P | No | EVA | |
| rs3389022528 | 431 | P>A | No | EVA | |
| rs48475746 | 440 | T>S | No | EVA | |
| rs254481642 | 501 | F>L | No | EVA |
No associated diseases with Q8C522
11 regional properties for Q8C522
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FERM domain | 211 - 492 | IPR000299 |
| domain | SAB domain | 661 - 709 | IPR007477 |
| domain | Band 4.1, C-terminal | 747 - 854 | IPR008379 |
| domain | FERM adjacent | 499 - 545 | IPR014847 |
| domain | FERM, N-terminal | 215 - 277 | IPR018979 |
| domain | FERM, C-terminal PH-like domain | 406 - 496 | IPR018980 |
| conserved_site | FERM conserved site | 265 - 293 | IPR019747-1 |
| conserved_site | FERM conserved site | 372 - 401 | IPR019747-2 |
| domain | FERM central domain | 295 - 402 | IPR019748 |
| domain | Band 4.1 domain | 207 - 402 | IPR019749 |
| domain | Band 4.1 protein, FERM domain, F1 sub-domain | 211 - 293 | IPR021187 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| metal ion binding | Binding to a metal ion. |
| nucleic acid binding | Binding to a nucleic acid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O94919 | ENDOD1 | Endonuclease domain-containing 1 protein | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGCARWLALG | GLLALAGLLQ | ARLLLPQQAG | FGECDRFFYK | GTPPAGLATE | AHVRICQRFA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSERFATLYS | PGHRIPVFSA | FRAARPASRS | AEQRGLLEPQ | IDDPDSNLEE | VIDEANALTS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VDNLGSKQAL | NADYIDSDYE | IGQLYPFPLN | SDLQMATFPL | TNSVPMTQSF | RERWHMNLNS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LMDRALIPHC | SEGKDLYILT | GAVPSEHRVK | GKVTIPEFVW | LAACCAVPGE | GWAMGFIKHT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QDIDVIEDVM | LRDLEKLLPH | KPQLFQDNCG | EMEQDTEKMK | KILEVVNQVQ | DEERSLQSQE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RMSPLASTQS | QRSALLSPEA | PPEGGSSFLG | QVLGFLATPF | IKLFQLIYYL | VTAVLRNIVH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLWLVAKQAI | NTVESCLYHL | GEATVSYLVA | IGQELVSIPW | KVLKVVAKVI | RAFLRILCCL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKAVCRALSI | PLRVLVDVAT | FPVYTVGAIP | IVCKDIAVGL | GGTLSLLFDT | AFGTVGGLFQ |
| 490 | 500 | ||||
| IVFSVFKRIG | YKVTLDNSGE | F |