Q8C2L6
Gene name |
Tmem161b |
Protein name |
Transmembrane protein 161B |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72745 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C2L6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C2L6-F1 | Predicted | AlphaFoldDB |
18 variants for Q8C2L6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3403992354 | 2 | G>C | No | EVA | |
| rs3404733835 | 4 | I>K | No | EVA | |
| rs3389288029 | 90 | V>I | No | EVA | |
| rs3389310476 | 108 | V>A | No | EVA | |
| rs3389307498 | 203 | N>K | No | EVA | |
| rs1131986071 | 208 | A>E | No | EVA | |
| rs1134467811 | 210 | Q>H | No | EVA | |
| rs3389302550 | 234 | V>I | No | EVA | |
| rs3389293184 | 238 | L>F | No | EVA | |
| rs3389307492 | 260 | M>L | No | EVA | |
| rs3389296957 | 271 | H>R | No | EVA | |
| rs263589257 | 276 | A>V | No | EVA | |
| rs3389293188 | 412 | V>E | No | EVA | |
| rs29251726 | 418 | A>S | No | EVA | |
| rs29251726 | 418 | A>T | No | EVA | |
| rs49611675 | 418 | A>V | No | EVA | |
| rs3404346199 | 428 | P>A | No | EVA | |
| rs3404734677 | 428 | P>R | No | EVA |
No associated diseases with Q8C2L6
No regional properties for Q8C2L6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8C2L6 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of cardiac muscle cell action potential | Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| regulation of heart rate | Any process that modulates the frequency or rate of heart contraction. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVIGIQLVV | TMVMASVMQK | IIPHYSLARW | LLCNGSLRWY | QHPSEEELRI | LAGKQQKGKS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKDRKYNGHI | ENKPLTIPKD | IDLHLETKSV | TEVDTLALHY | FPEYQWLVDF | TVAATIVYLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TEVYYSFMKP | TQEMNISLVW | CLLVLSFAIK | VLFSLTTHYF | KVEDGGERSV | CVTFGFFFFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KAMAVLIVTE | NYLEFGLETG | FTNFSDSAMQ | FLEKQGLESQ | GPVSKLTFKF | FLAVFCSLIG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AFLTFPGLRL | AQMHLDALNM | ATEKITQTLL | HINFLAPLFM | VLLWVKPITK | DYIMNPPLGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESVPLMTEAT | FDTLRLWLII | LLCVLRLAMM | RSHLQAYLNL | AQKCVDQMKK | EAGRISTVEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QKMVARVFYY | LCVIALQYVA | PLVMLLHMTL | LLKTLGNHSW | GIYPEAAFPL | PVDNNLPANS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AYPELPSPDG | KMKVTVTQIT | VALSSLKNIF | TPLLFRGLLS | FLTWWIAACL | FSTSLFGLFY |
| HQYLTVA |