Q8C176

PR
Gene name
Taf2
Protein name
Transcription initiation factor TFIID subunit 2
Names
TBP-associated factor 150 kDa, Transcription initiation factor TFIID 150 kDa subunit, TAF(II)150, TAFII-150, TAFII150
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1018-1104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8C176

Entry ID Method Resolution Chain Position Source
AF-Q8C176-F1 Predicted AlphaFoldDB

No variants for Q8C176

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8C176

No associated diseases with Q8C176

No regional properties for Q8C176

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8C176

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
transcription factor TFTC complex A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.

2 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

12 GO annotations of biological process

Name Definition
G2/M transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
histone H3 acetylation The modification of histone H3 by the addition of an acetyl group.
monoubiquitinated histone deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone protein.
monoubiquitinated histone H2A deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
mRNA transcription by RNA polymerase II The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of transcription initiation by RNA polymerase II Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of DNA repair Any process that modulates the frequency, rate or extent of DNA repair.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
RNA polymerase II preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6P1X5 TAF2 Transcription initiation factor TFIID subunit 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MNRKKGDKGF ESPRPYKLTH QVVCINNINF QRKSVVGFVE LTIFPTVANL NRIKLNSKQC
70 80 90 100 110 120
RIYRVRINDL EAAFIYNDPT LEVCHSESKQ RNLNYFSNAY AAAVSAVDPD AGNGELCIKV
130 140 150 160 170 180
PSELWKHVDE LKVLKIHINF SLDQPKGGLH FVVPSVEGSM AERGAHVFSC GYQNSTRFWF
190 200 210 220 230 240
PCVDSYSELC TWKLEFTVDA AMVAVSNGDL VETVYTHDMR KKTFHYMLTI PTAASNISLA
250 260 270 280 290 300
IGPFEILVDP YMHEVTHFCL PQLLPLLKHT TSYIHEVFEF YEEILTCRYP YSCFKTVFID
310 320 330 340 350 360
EAYVEVAAYA SMSIFSTNLL HSAMIIDETP LTRRCLAQAL AQQFFGCFIS RMSWSDEWVL
370 380 390 400 410 420
KGISGYIYGL WMKKTFGVNE YHHWIKEELD KIVAYELKTG GVLLHPIFGG GKEKDNPASH
430 440 450 460 470 480
LHFSIKHPHT LSWEYYTMFQ CKAHLVMRLI ENRISMEFML QVFNKLLSLA STASSQKFQS
490 500 510 520 530 540
HMWSQMLVST YGFLKSISNV SGKDIQPLIK QWLDQSGVVK FYGSFAFNRK RNVLELEIKQ
550 560 570 580 590 600
DYTSPGTQKY VGPLKVTVQE LDGSFNHTLQ IEENSLKHDI PCHSKSRRNK KKKIPLMNGE
610 620 630 640 650 660
EVDMDLSAME ADSPLLWIRI DPDMSVLRKV EFEQADFMWQ YELRYERDVV AQQESILALE
670 680 690 700 710 720
KFPTPASRLA LTDILEQEQC FYRVRMSACF CLAKIANSMV STWTGPPAMK SLFTRMFCCK
730 740 750 760 770 780
TCPNIVKTNN FMSFQSYFLQ KTMPVAMALL RDVHNLCPKE VLTFILDLIK YNDNRKNKFS
790 800 810 820 830 840
DNYYRAEMID ALANSVTPAV SVNNEVRTLD NLNPDVRLIL EEITRFLNME KLLPSYRHTI
850 860 870 880 890 900
TVSCLRAIRV LQKNGHVPSD ASLFKSYAEY GHFVDIRIAA LEAVVDYTKV DRSYEELQWL
910 920 930 940 950 960
LNMIQTDPVP YVRHKILNML TKNPPFTKNM ESPLCNEALV DQLWKLMNSG TAHDWRLRCG
970 980 990 1000 1010 1020
AVDLYFTLFG LSRPSCLPLP ELGLVLNLKE KKAVLNPTII PEAGVGNQFS SSQDEEEVDM
1030 1040 1050 1060 1070 1080
DTVHDSQAFI SHHLNMLERP STPGLSKYRP HHHHHHHEHK KKKKKHKHKH KHKHKHDSKD
1090 1100
KDREPFAFSS PASGRSVRSP SLSD