AiPD: Autoinhibited Protein Database

Gene name	Slc39a6 (Zip6)
Protein name	Zinc transporter ZIP6
Names	Endoplasmic reticulum membrane-linked protein, Ermelin, Solute carrier family 39 member 6, Zrt- and Irt-like protein 6, ZIP-6
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:106957
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

132-208 (Predicted disordered autoinhibitory region) PR

132-208 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8C145-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389489276	8	I>F	No	EVA
rs3389490880	30	F>Y	No	EVA
rs3389486180	42	E>V	No	EVA
rs3389506744	52	T>A	No	EVA
rs3389489297	89	K>E	No	EVA
rs3389470800	92	H>Q	No	EVA
rs3389490401	111	H>Q	No	EVA
rs3389493785	122	E>K	No	EVA
rs3389448812	135	H>L	No	EVA
rs3389448812	135	H>R	No	EVA
rs3389502382	194	V>A	No	EVA
rs3389506692	218	G>R	No	EVA
rs3389490833	308	D>Y	No	EVA
rs3389448743	331	L>S	No	EVA
rs3389505925	363	F>L	No	EVA
rs31475812	396	Q>H	No	EVA
rs3389487413	413	L>M	No	EVA
rs3389448768	482	K>T	No	EVA
rs3389457274	489	S>*	No	EVA
rs3389457263	496	P>A	No	EVA
rs3389489270	501	E>D	No	EVA
rs3389486119	509	Q>K	No	EVA
rs236957565	513	P>A	No	EVA
rs246674493	596	E>Q	No	EVA
rs3389489363	604	T>S	No	EVA
rs3408270775	605	L>M	No	EVA
rs3389469709	622	L>R	No	EVA
rs3389486145	694	N>I	No	EVA
rs3389448749	749	M>I	No	EVA
rs31474577	762	R>H	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8C145

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Cell projection, lamellipodium membrane ; Multi-pass membrane protein Membrane raft ; Multi-pass membrane protein Apical cell membrane	Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (By similarity) In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lamellipodium membrane	The portion of the plasma membrane surrounding a lamellipodium.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
zinc ion transmembrane transporter activity	Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.

Name	Definition
cellular zinc ion homeostasis	Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
zinc ion import across plasma membrane	The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol.
zinc ion transmembrane transport	A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins