AiPD: Autoinhibited Protein Database

Gene name	Terb1
Protein name	Telomere repeats-binding bouquet formation protein 1
Names	Coiled-coil domain-containing protein 79
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:320022
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

503-575 (Predicted disordered autoinhibitory region) PR

503-575 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1X58	NMR	-	A	712-760	PDB
AF-Q8C0V1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389003257	22	C>S	No	EVA
rs3388997741	38	I>M	No	EVA
rs3389009494	98	C>Y	No	EVA
rs3389007468	105	D>E	No	EVA
rs3388997324	142	R>S	No	EVA
rs242070065	206	C>Y	No	EVA
rs3388973381	267	S>I	No	EVA
rs3389007440	277	T>I	No	EVA
rs239975005	363	T>I	No	EVA
rs1132577061	377	S>C	No	EVA
rs1133919371	382	Q>K	No	EVA
rs1133353256	387	E>A	No	EVA
rs1134586378	390	I>T	No	EVA
rs259688326	451	R>G	No	EVA
rs3389009462	453	C>S	No	EVA
rs3389005753	455	D>G	No	EVA
rs3388980931	462	A>T	No	EVA
rs240256594	464	D>N	No	EVA
rs30868152	485	A>G	No	EVA
rs3389010399	486	C>Y	No	EVA
rs264979829	503	H>N	No	EVA
rs242199743	512	S>N	No	EVA
rs3389005903	514	I>L	No	EVA
rs30868149	528	K>E	No	EVA
rs30871622	553	V>A	No	EVA
rs3389010364	568	C>*	No	EVA
rs250804485	587	M>L	No	EVA
rs30867332	598	A>V	No	EVA
rs3389003249	611	L>S	No	EVA
rs3388955572	725	H>Q	No	EVA
rs3388997323	731	G>R	No	EVA
rs256915772	760	I>M	No	EVA

Type	Name	Position	InterPro Accession
repeat	Armadillo	101 - 145	IPR000225
domain	SANT/Myb domain	711 - 762	IPR001005

		Description
EC Number
Subcellular Localization	Chromosome, telomere Nucleus inner membrane	Localizes to telomeres during meiotic prophase (PubMed:24413433) In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane (PubMed:26548954)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome, telomeric region	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
nuclear inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.

Name	Definition
No GO annotations for molecular function

Name	Definition
homologous chromosome pairing at meiosis	The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
meiotic attachment of telomere to nuclear envelope	The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation.
meiotic telomere clustering	The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins