AiPD: Autoinhibited Protein Database

Gene name	Trub1
Protein name	Pseudouridylate synthase TRUB1
Names	TruB pseudouridine synthase homolog 1, tRNA pseudouridine 55 synthase TRUB1, Psi55 synthase TRUB1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:72133
EC number	5.4.99.25: Transferring other groups
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-95 (Predicted disordered autoinhibitory region) PR

1-95 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8C0D0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3409881808	7	E>DVCVE*	No	EVA
rs3389527820	13	I>F	No	EVA
rs3389550132	17	A>T	No	EVA
rs3409434392	49	L>R	No	EVA
rs249253439	56	L>M	No	EVA
rs3389505531	60	F>I	No	EVA
rs1133334873	81	L>V	No	EVA
rs1133705722	83	A>V	No	EVA
rs247760479	89	S>F	No	EVA
rs3389541444	110	S>N	No	EVA
rs3389552645	133	G>R	No	EVA
rs3409881838	137	Y>F	No	EVA
rs219539208	139	T>A	No	EVA
rs3389559740	193	K>N	No	EVA
rs1133536233	212	P>L	No	EVA
rs3389545014	216	V>A	No	EVA
rs3389541509	240	G>D	No	EVA
rs3389527807	248	S>N	No	EVA
rs36973114	289	E>K	No	EVA
rs3389545003	301	E>D	No	EVA
rs3389542326	306	K>R	No	EVA
rs3389541478	325	L>F	No	EVA
rs248991674	327	D>E	No	EVA

Type	Name	Position	InterPro Accession
domain	Peptidyl-prolyl cis-trans isomerase, PpiC-type	173 - 271	IPR000297-1
domain	Peptidyl-prolyl cis-trans isomerase, PpiC-type	280 - 380	IPR000297-2
domain	SurA N-terminal	27 - 144	IPR015391

		Description
EC Number	5.4.99.25	Transferring other groups
Subcellular Localization	Nucleus Cytoplasm, cytosol	Catalyzes pseudouridylation of mRNAs in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
pre-miRNA binding	Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.
pseudouridine synthase activity	Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

Name	Definition
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
mRNA pseudouridine synthesis	The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.
positive regulation of pre-miRNA processing	Any process that activates or increases the frequency, rate or extent of pre-microRNA processing.
tRNA modification	The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	Homo sapiens (Human)	PR
Q8WWH5	TRUB1	Pseudouridylate synthase TRUB1	Homo sapiens (Human)	PR