Q8BZI0
Gene name |
Afap1l1 |
Protein name |
Actin filament-associated protein 1-like 1 |
Names |
AFAP1-like protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:106877 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BZI0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BZI0-F1 | Predicted | AlphaFoldDB |
35 variants for Q8BZI0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389501921 | 30 | T>I | No | EVA | |
| rs3389463127 | 88 | D>* | No | EVA | |
| rs3389517963 | 89 | D>A | No | EVA | |
| rs3389415719 | 152 | Q>* | No | EVA | |
| rs3389463135 | 195 | E>* | No | EVA | |
| rs3389498754 | 198 | E>G | No | EVA | |
| rs3389521254 | 268 | C>S | No | EVA | |
| rs3408692190 | 290 | A>G | No | EVA | |
| rs3389498687 | 352 | D>G | No | EVA | |
| rs239457330 | 362 | T>S | No | EVA | |
| rs36351628 | 364 | G>S | No | EVA | |
| rs3389521321 | 389 | A>P | No | EVA | |
| rs3389506453 | 392 | R>C | No | EVA | |
| rs36718800 | 418 | E>* | No | EVA | |
| rs36718800 | 418 | E>K | No | EVA | |
| rs3389515244 | 439 | R>S | No | EVA | |
| rs3389515195 | 440 | L>F | No | EVA | |
| rs3389521262 | 441 | R>M | No | EVA | |
| rs3389510297 | 448 | H>N | No | EVA | |
| rs3389517968 | 468 | V>I | No | EVA | |
| rs3389510231 | 475 | R>W | No | EVA | |
| rs3389515229 | 480 | F>I | No | EVA | |
| rs3389415779 | 517 | P>Q | No | EVA | |
| rs3389515248 | 525 | V>D | No | EVA | |
| rs3389521274 | 545 | Q>* | No | EVA | |
| rs29671446 | 570 | P>L | No | EVA | |
| rs218271783 | 635 | T>M | No | EVA | |
| rs3389415751 | 638 | T>I | No | EVA | |
| rs3389471832 | 646 | E>* | No | EVA | |
| rs3389415725 | 656 | N>K | No | EVA | |
| rs256354152 | 658 | P>S | No | EVA | |
| rs3389485166 | 669 | V>M | No | EVA | |
| rs3389463078 | 692 | A>V | No | EVA | |
| rs3389521299 | 705 | P>L | No | EVA | |
| rs3389506364 | 724 | P>S | No | EVA |
No associated diseases with Q8BZI0
1 regional properties for Q8BZI0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thioredoxin domain | 73 - 156 | IPR013766 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| podosome | An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TED9 | AFAP1L1 | Actin filament-associated protein 1-like 1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRSRVLEQL | IPELTGLLSL | LDHEYLSDST | LEKKMAVASL | LQSLQPLPAK | EVSFLYVNTA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLHSGPSFVE | SLFEEFDCDL | GDLRDMSDDG | EPSKGASPEP | TKSPSLRSAA | ADVPPPLPNK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PPPEDYYEEA | LPLGPGKSPE | YISSHNGCSP | AQSIVDGYYE | DADNSYPTTR | MNGELKNSYN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSDAMSSSYE | SYDEEEEEEK | GRQPKHQWPS | EEASMHLVRD | CRICAFLLRK | KRFGQWAKQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TVIKEEQLLC | YKSSKDRQPH | LRLALDVCTV | IYVPKDSRHK | RHELRFSQGA | TEVLVLALQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| REQAEEWLKV | IREVSRPIVG | AEGLEVPRSP | VILCKADQDK | RLSQEKQNSD | SDSLGMNDSG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| STLGRREACE | HGKGKKNSLA | ELKGSMSRAA | GRKITRIISF | SKKKALSEDL | QTFSSEDEVP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CCGYLNVLVN | QGWKERWCRL | RCNTLYFHKD | RTDLHTHVNS | IALRGCEVAP | GFGPRHPFAF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RILRNRQEVA | ILEASCSEDM | GRWLGLLLVE | MGSKVTPEAL | HYDYVDVETL | TSIVSAGRNS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FLYAQSCQDQ | WPEPRIYDEV | PYEKVQDEEP | QRPTGAQVKR | HASSCSEKSH | RADPQVKVKR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HASSANQYKY | GKNRAEEDAR | RYLVEKERLE | KEKETIRTEL | TALRQEKKEL | KEAIRNNPGA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KSKALEEAVA | TLEAQCRAKE | EQRIDLELKL | VAVKERLQQS | LAGGPALGLS | VSNKNKSQDT |
| 730 | 740 | 750 | 760 | ||
| TNKPQSNAPE | QSLPVNCVSE | LRKRSPSIVT | SNQGRVLQKA | KEWEMKKT |