Q8BYZ1

PR
Gene name
Abi3 (Nesh)
Protein name
ABI gene family member 3
Names
New molecule including SH3, Nesh
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66610
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

130-261 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BYZ1

Entry ID Method Resolution Chain Position Source
AF-Q8BYZ1-F1 Predicted AlphaFoldDB

17 variants for Q8BYZ1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3402715568 6 Q>L No EVA
rs3402626042 8 Q>* No EVA
rs3402652316 9 Q>L No EVA
rs3389182465 26 H>Q No EVA
rs3389193809 27 S>R No EVA
rs3389130979 46 K>R No EVA
rs3389203748 82 Q>H No EVA
rs3389195343 97 G>D No EVA
rs3389195332 160 S>I No EVA
rs3401418018 218 G>D No EVA
rs3389196967 229 S>P No EVA
rs29392269 240 P>L No EVA
rs3389198494 245 P>H No EVA
rs3389189852 246 V>A No EVA
rs3389171400 262 P>T No EVA
rs240018814 271 L>P No EVA
rs3389171406 313 K>* No EVA

No associated diseases with Q8BYZ1

No regional properties for Q8BYZ1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8BYZ1

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
SCAR complex A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.

3 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
identical protein binding Binding to an identical protein or proteins.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

9 GO annotations of biological process

Name Definition
defense response to tumor cell Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
negative regulation of lamellipodium assembly Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
negative regulation of protein localization to plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of cellular senescence Any process that activates or increases the frequency, rate or extent of cellular senescence.
positive regulation of protein tyrosine kinase activity Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
regulation of actin cytoskeleton reorganization Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of dendritic spine morphogenesis Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
regulation of postsynaptic density assembly Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9P2A4 ABI3 ABI gene family member 3 Homo sapiens (Human) PR
10 20 30 40 50 60
MAELQQLQQL QEFDIPTGRE ALRGNHSALL RVANYCEDNY LQATDKRKAL EETMAFTTQA
70 80 90 100 110 120
LASVAYQVGN LAGHTLRMLD LQGAALRQVE AKMSTLGQMV NMHMEKVARR EIGTLATVVR
130 140 150 160 170 180
LPSNQKVIPP ESLPSLTPYH RKPLNFACLD DIGHGVKDLS TQLSRTGTLS RKSIKAPATP
190 200 210 220 230 240
VSATLGRPPR IPEPVQLPAV PDGKLSAASS ASSLASAGSA EGASGIPQSK GQVAPATPPP
250 260 270 280 290 300
PPVAPVTPPP PPLSAEVFLP PPPLEVSQPP LEAELPLPPP PALEGDELGL LPPPPPGFGP
310 320 330 340 350 360
DEPSWVPASY LEKVVTLYPY TRQKDNELSF SEGTVICVTR RYSDGWCEGV SSEGTGFFPG
NYVEPSC