Q8BYC4

PR
Gene name
Gpr20
Protein name
G-protein coupled receptor 20
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:239530
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

291-358 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BYC4

Entry ID Method Resolution Chain Position Source
AF-Q8BYC4-F1 Predicted AlphaFoldDB

16 variants for Q8BYC4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389336682 5 L>W No EVA
rs3389359372 10 W>* No EVA
rs3389359092 13 A>T No EVA
rs3389316566 27 V>L No EVA
rs49778102 38 R>W No EVA
rs3389372087 51 W>R No EVA
rs3389326774 113 G>D No EVA
rs258790125 115 R>P No EVA
rs3389326789 121 A>V No EVA
rs3389355353 130 L>I No EVA
rs3389367859 135 S>F No EVA
rs3389336736 157 R>H No EVA
rs3389375638 192 S>T No EVA
rs3389365517 343 I>F No EVA
rs3389365594 344 G>A No EVA
rs3389346271 345 S>P No EVA

No associated diseases with Q8BYC4

1 regional properties for Q8BYC4

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 68 - 296 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

1 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

2 GO annotations of biological process

Name Definition
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
positive regulation of Rho protein signal transduction Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8BUD0 Gpr4 G-protein coupled receptor 4 Mus musculus (Mouse) PR
10 20 30 40 50 60
MPSALSMRPW DAALPNTTAA AWTNGSVPEM PLFHHFARLD EELQATFPSL WQALMVVHGT
70 80 90 100 110 120
IFLAGLVLNG LALYVFCCRT RAKTPSVTYT INLVVTDLLV GLSLPTRFAV FYGARGCLRC
130 140 150 160 170 180
AFPHVLGYFL NMHCSILFLT CICVDRYLAI VQPEGSRRWR QPACAKAVCI FVWLAAGVVT
190 200 210 220 230 240
LSVLGVKSGG RSCCRVFALT VLEFLLPLLV ISVFTGRIMC ALSRPGLLRQ GRQRRVRAMQ
250 260 270 280 290 300
LLLTVLVIFL VCFTPFHARQ VAVALWPNVP KHTSLVAYHV AVTLSSLNSC MDPIVYCFIT
310 320 330 340 350
SGFQATVRGL FYQRGEEFKP SSMDVVSMHK STKASAPIHI LSIGSHTLTQ PLTNGPEP