Q8BWT5
PR
Gene name |
Dip2a (Dip2, Kiaa0184) |
Protein name |
Disco-interacting protein 2 homolog A |
Names |
DIP2 homolog A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:64451 |
EC number |
6.2.1.1: Acid--thiol ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BWT5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BWT5-F1 | Predicted | AlphaFoldDB |
73 variants for Q8BWT5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389108696 | 36 | K>* | No | EVA | |
| rs3389109979 | 97 | S>L | No | EVA | |
| rs3389108658 | 107 | R>L | No | EVA | |
| rs3401600783 | 129 | R>S | No | EVA | |
| rs256793985 | 150 | R>G | No | EVA | |
| rs578840556 | 161 | L>P | No | EVA | |
| rs585005631 | 163 | G>R | No | EVA | |
| rs3389103664 | 176 | P>Q | No | EVA | |
| rs30048701 | 188 | S>P | No | EVA | |
| rs3389110234 | 195 | A>T | No | EVA | |
| rs3389104931 | 267 | D>V | No | EVA | |
| rs240218323 | 282 | N>T | No | EVA | |
| rs264312111 | 282 | N>Y | No | EVA | |
| rs3389113346 | 297 | T>I | No | EVA | |
| rs3389109959 | 298 | Q>K | No | EVA | |
| rs3389116768 | 380 | I>L | No | EVA | |
| rs3389104872 | 388 | D>V | No | EVA | |
| rs3389116816 | 389 | A>V | No | EVA | |
| rs864278690 | 391 | S>G | No | EVA | |
| rs3389110188 | 393 | Q>H | No | EVA | |
| rs3389100111 | 402 | G>R | No | EVA | |
| rs3389095436 | 442 | H>R | No | EVA | |
| rs3401235927 | 532 | I>S | No | EVA | |
| rs3389073256 | 535 | A>V | No | EVA | |
| rs3389108668 | 539 | V>I | No | EVA | |
| rs864285849 | 650 | L>R | No | EVA | |
| rs3401490574 | 673 | Q>R | No | EVA | |
| rs3389104880 | 676 | P>R | No | EVA | |
| rs3389113273 | 688 | A>G | No | EVA | |
| rs3389085767 | 717 | I>F | No | EVA | |
| rs3389103657 | 719 | K>E | No | EVA | |
| rs3389116731 | 732 | V>L | No | EVA | |
| rs3389106621 | 749 | G>R | No | EVA | |
| rs3389106582 | 768 | V>I | No | EVA | |
| rs3389095410 | 795 | A>T | No | EVA | |
| rs3389110046 | 797 | F>Y | No | EVA | |
| rs212713666 | 814 | R>W | No | EVA | |
| rs3389085781 | 823 | F>I | No | EVA | |
| rs3389106593 | 887 | V>L | No | EVA | |
| rs3401323442 | 895 | Q>* | No | EVA | |
| rs3389108679 | 896 | K>I | No | EVA | |
| rs217386451 | 899 | E>D | No | EVA | |
| rs3389119152 | 902 | P>S | No | EVA | |
| rs3389108040 | 927 | L>Q | No | EVA | |
| rs3389108702 | 929 | D>N | No | EVA | |
| rs3389109994 | 938 | F>S | No | EVA | |
| rs3389113315 | 944 | Q>* | No | EVA | |
| rs3389103660 | 965 | V>L | No | EVA | |
| rs3413090103 | 968 | T>S | No | EVA | |
| rs3389085830 | 975 | H>L | No | EVA | |
| rs3389100037 | 987 | E>K | No | EVA | |
| rs3389095439 | 1013 | G>D | No | EVA | |
| rs3401429404 | 1067 | A>S | No | EVA | |
| rs3389050165 | 1073 | R>M | No | EVA | |
| rs3389085812 | 1108 | V>E | No | EVA | |
| rs3389106633 | 1109 | S>* | No | EVA | |
| rs3389109966 | 1110 | T>W | No | EVA | |
| rs30050232 | 1123 | A>T | No | EVA | |
| rs3389085735 | 1138 | Y>H | No | EVA | |
| rs234640159 | 1163 | V>I | No | EVA | |
| rs3412971207 | 1177 | L>R | No | EVA | |
| rs3389095496 | 1205 | M>V | No | EVA | |
| rs3401102249 | 1230 | C>* | No | EVA | |
| rs3389085823 | 1243 | T>I | No | EVA | |
| rs3389108037 | 1301 | E>S | No | EVA | |
| rs3389113268 | 1304 | S>F | No | EVA | |
| rs3389116762 | 1375 | T>I | No | EVA | |
| rs3389108653 | 1458 | L>P | No | EVA | |
| rs3389050238 | 1480 | V>E | No | EVA | |
| rs3389095408 | 1484 | V>L | No | EVA | |
| rs3389095408 | 1484 | V>M | No | EVA | |
| rs3389080695 | 1498 | G>D | No | EVA | |
| rs3389050232 | 1502 | R>P | No | EVA |
No associated diseases with Q8BWT5
5 regional properties for Q8BWT5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AMP-dependent synthetase/ligase domain | 297 - 766 | IPR000873-1 |
| domain | AMP-dependent synthetase/ligase domain | 943 - 1416 | IPR000873-2 |
| domain | DMAP1-binding domain | 9 - 105 | IPR010506 |
| domain | Dip2-like domain | 303 - 879 | IPR037337-1 |
| domain | Dip2-like domain | 955 - 1519 | IPR037337-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.2.1.1 | Acid--thiol ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetate-CoA ligase activity | Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| acetyl-CoA biosynthetic process | The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. |
| dendritic spine morphogenesis | The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of peptidyl-lysine acetylation | Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADRGCPLEA | APLPAEVLES | LAELELELSE | GDITQKGYEK | KRAKLLARYI | PLIQDVHTEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VQAALAKYKE | RKMPMPSKRR | SALVHSSVET | YTPPDTSSAS | EDEGSLRRPG | RLTSTLLQSH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGIEPWLDRV | IQGSSTSSSA | SSTSSHPGGR | PAAAPSASTA | LAGLTAHAHI | DLHSAPPDVT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGLVEHSSYE | RPQMASVRGI | PRGHGRNVLE | TADGVPVNSR | VSSKIQQLLN | TLKRPKRPPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEFFVDDFEE | LLEVQQPDPN | QPKPEGDQMA | VLKGEPLSVG | TNGPLSLLAA | LQLWGTTQPK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| APCLTALDTA | GKATCTLTYG | KLWSRSLKLA | YTLLNKLTSK | NEPLLNPGDR | VALVFPNSDP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VMFMVAFYGC | LLAELVPVPI | EVPLTRKDAG | SQQVGFLLGS | CGVTLALTTD | ACQKGLPKAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TGEVATFKGW | PPLAWLVIDG | KHLTRPPKDW | YPLAQDTGSR | TAYIEYKTSK | EGSTVGVTVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HSSLLAQCQA | LTQACGYTEA | ETLTNVLDFK | RDAGLWHGVL | TSVMNRMHVI | TIPYALMKVN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PLSWIQKVCS | YKARAALVKS | RDMHWSLLAQ | RGQRDVCLSS | LRMLIVADGA | NPWSISSCDA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FLNVFQSRGL | RPEVICPCAS | SPEALTVAIR | RPPDLGGPPP | RKAVLSMNGL | SYGVIRVDTE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EKLSVLTVQD | VGQVMPGASV | CVVKVDGAPY | LCKTDEIGEI | CVNSVATGTA | YYGLLGITKN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TFETVPVTAD | GVPVSDRPFT | RTGLLGFIGP | DNLVFVVGKL | DGLMVVGVRR | HNADDIVATA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LAVEPMKFVY | RGRIAVFSVT | VLHDDRIVLV | AEQRPDASEE | DSFQWMSRVL | QAIDSIHQVG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VYCLALVPAN | TLPKAPLGGI | HISETKQRFL | EGTLHPCNVL | MCPHTCVTNL | PKPRQKQPEV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GPASMIVGNL | VAGKRIAQAS | GRELAHLEDS | DQARKFLFLA | DVLQWRAHTT | PDHPLFLLLN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AKGTVTSTAT | CIQLHKRAER | VAAALMEKGR | LDAGDHVALV | YPPGVDLIAA | FYGCLYCGCV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| PVTVRPPHPQ | NLGTTLPTVK | MIVEVSKSAC | VLSTQAITRL | LKSKEAAAAV | DVRTWPTILD |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TDDIPKKKVA | SIFRPPSPDV | LAYLDFSVST | TGILAGVKMS | HAATSALCRS | IKLQCELYPS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RQIAICLDPY | CGLGFALWCL | CSVYSGHQSV | LVPPLELESN | VSLWLSAVSQ | YKARVTFCSY |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SVMEMCTKGL | GAQTGALRMK | GVNLSCVRTC | MVVAEERPRI | SLTQSFSKLF | KDLGLPARAV |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| STTFGCRVNV | AICLQGTTGP | DPTTVYVDMR | ALRHDRVRLV | ERGSPHSLPL | MESGKILPGV |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KVIIAHTETK | GPLGDSHLGE | IWVSSPHNAT | GYYTVYGEET | LHADHFSARL | SFGDTQTIWA |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| RTGYLGFLRR | TELTDASGER | HDALYVVGSL | DETLELRGMR | YHPIDIETSV | IRAHRSIAEC |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| AVFTWTNLLV | VVVELDGLEQ | DALDLVALVT | NVVLEEHYLV | VGVVVIVDPG | VIPINSRGEK |
| 1510 | 1520 | ||||
| QRMHLRDGFL | ADQLDPIYVA | YNM |