Q8BW72
PR
Gene name |
Kdm4a (Jhdm3a, Jmjd2, Jmjd2a, Kiaa0677) |
Protein name |
Lysine-specific demethylase 4A |
Names |
JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:230674 |
EC number |
1.14.11.66: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BW72
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BW72-F1 | Predicted | AlphaFoldDB |
49 variants for Q8BW72
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388711827 | 3 | S>P | No | EVA | |
| rs3388707140 | 35 | E>G | No | EVA | |
| rs3388697691 | 78 | Q>H | No | EVA | |
| rs3394747880 | 172 | N>Y | No | EVA | |
| rs3388693760 | 226 | F>L | No | EVA | |
| rs3388701009 | 276 | H>L | No | EVA | |
| rs3388705254 | 276 | H>N | No | EVA | |
| rs108164154 | 295 | R>Q | No | EVA | |
| rs32685815 | 339 | M>T | No | EVA | |
| rs263908480 | 378 | D>E | No | EVA | |
| rs3388700998 | 380 | G>* | No | EVA | |
| rs3388697615 | 405 | I>M | No | EVA | |
| rs3388704286 | 406 | P>T | No | EVA | |
| rs3388701008 | 459 | P>L | No | EVA | |
| rs251707744 | 495 | V>G | No | EVA | |
| rs3388709611 | 513 | G>A | No | EVA | |
| rs3388707692 | 533 | C>R | No | EVA | |
| rs3388704291 | 538 | K>* | No | EVA | |
| rs235422035 | 552 | G>S | No | EVA | |
| rs3388697653 | 553 | K>M | No | EVA | |
| rs3388683200 | 564 | K>N | No | EVA | |
| rs3388683226 | 573 | E>D | No | EVA | |
| rs3394660682 | 621 | S>A | No | EVA | |
| rs3394808036 | 622 | E>Q | No | EVA | |
| rs3394730846 | 623 | Q>K | No | EVA | |
| rs3394481679 | 626 | P>S | No | EVA | |
| rs265536407 | 684 | A>V | No | EVA | |
| rs3388705340 | 730 | D>E | No | EVA | |
| rs1134470070 | 754 | P>L | No | EVA | |
| rs3388683165 | 780 | L>* | No | EVA | |
| rs3388701041 | 781 | R>C | No | EVA | |
| rs3388697629 | 788 | A>V | No | EVA | |
| rs3388707117 | 831 | V>D | No | EVA | |
| rs3388706266 | 835 | K>E | No | EVA | |
| rs3388711778 | 843 | C>Y | No | EVA | |
| rs3388691734 | 856 | F>I | No | EVA | |
| rs3388705286 | 857 | H>Q | No | EVA | |
| rs3388711771 | 859 | S>N | No | EVA | |
| rs3388691724 | 865 | G>A | No | EVA | |
| rs3388704366 | 868 | M>I | No | EVA | |
| rs3388704292 | 871 | D>E | No | EVA | |
| rs3388706272 | 875 | F>S | No | EVA | |
| rs3388704372 | 883 | R>C | No | EVA | |
| rs3388704330 | 929 | E>V | No | EVA | |
| rs3394217947 | 947 | V>T | No | EVA | |
| rs3388700674 | 973 | Y>S | No | EVA | |
| rs3394730805 | 979 | A>P | No | EVA | |
| rs3394748858 | 1048 | R>W | No | EVA | |
| rs3388706231 | 1057 | A>T | No | EVA |
No associated diseases with Q8BW72
12 regional properties for Q8BW72
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, PHD-type | 709 - 767 | IPR001965-1 |
| domain | Zinc finger, PHD-type | 829 - 885 | IPR001965-2 |
| domain | Tudor domain | 897 - 954 | IPR002999-1 |
| domain | Tudor domain | 955 - 1011 | IPR002999-2 |
| domain | JmjC domain | 142 - 308 | IPR003347 |
| domain | JmjN domain | 13 - 56 | IPR003349 |
| domain | Extended PHD (ePHD) domain | 772 - 885 | IPR034732 |
| domain | Lysine-specific demethylase 4-like, Tudor domain | 902 - 936 | IPR040477-1 |
| domain | Lysine-specific demethylase 4-like, Tudor domain | 960 - 994 | IPR040477-2 |
| domain | Lysine-specific demethylase 4A, first Tudor domain | 899 - 953 | IPR047479 |
| domain | Lysine-specific demethylase 4A, second Tudor domain | 956 - 1011 | IPR047481 |
| domain | Lysine-specific demethylase 4A, extended PHD finger | 775 - 884 | IPR047482 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.11.66 | With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pericentric heterochromatin | Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone demethylase activity | Catalysis of the removal of a methyl group from a histone. |
| histone H3-methyl-lysine-36 demethylase activity | Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. |
| histone H3-methyl-lysine-9 demethylase activity | Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. |
| histone H3-tri/dimethyl-lysine-36 demethylase activity | Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. |
| histone H3-tri/dimethyl-lysine-9 demethylase activity | Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| zinc ion binding | Binding to a zinc ion (Zn). |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac muscle hypertrophy in response to stress | The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone demethylation | The modification of histones by removal of methyl groups. |
| histone H3-K36 demethylation | The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone. |
| histone H3-K9 demethylation | The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone. |
| negative regulation of astrocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. |
| negative regulation of autophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| negative regulation of cell death | Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of histone H3-K9 trimethylation | Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of neuron differentiation | Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
| response to nutrient levels | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O94953 | KDM4B | Lysine-specific demethylase 4B | Homo sapiens (Human) | PR |
| O75164 | KDM4A | Lysine-specific demethylase 4A | Homo sapiens (Human) | PR |
| Q62240 | Kdm5d | Lysine-specific demethylase 5D | Mus musculus (Mouse) | PR |
| Q3U2K5 | Kdm4d | Lysine-specific demethylase 4D | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASESETLNP | SARIMTFYPT | MEEFRNFSRY | IAYIESQGAH | RAGLAKVVPP | KEWKPRTSYD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DIDDLVIPAP | IQQLVTGQSG | LFTQYNIQKK | AMTVREFRKI | ANSDKYCTPR | YSEFEELERK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YWKNLTFNPP | IYGADVNGTL | YEQHVDEWNI | GRLKTILDLV | EKESGITIEG | VNTPYLYFGM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WKTSFAWHTE | DMDLYSINYL | HFGEPKSWYS | VPPEHGKRLE | RLAKGFFPGS | AQSCEAFLRH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KMTLISPLML | KKYGIPFDKV | TQEAGEFMIT | FPYGYHAGFN | HGFNCAESTN | FATRRWIEYG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KQAVLCSCRK | DMVKISMDVF | VRRFQPERYK | LWKAGKDSMV | IDHTLPTPEA | AEFLKDSGGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TPRAGSEECP | EEDVEAADQG | EEGDVKRSLA | KHRIGTKRHR | VCLEIPQEVS | QSELFPKEEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSGQYEMTEC | PATLAPVRPT | HSSVRQVEDS | LPFPDYSDPT | EVKFEELKNV | KLEEEDEEDE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PEAAALDLSV | NPASVGGRLV | FSGSKKKSSS | SLGSTSSQDS | VSSDSETAES | VSCQGQEKTG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VLTVHSYARG | DGKAATGEPS | VKKKRSAPRS | ISEQELAEVA | DEYMLSLEEN | KKTKGRRQPL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SKLPRHHPLV | LQECGSDDET | SEQLTPEEEA | EETEAWAKPL | SQLWQNRPPN | FEAEKEFNEI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MAQQAPHCAV | CMIFQTYHQV | EFGAFSQSCG | DASEPAAQTQ | RTKPLIPEMC | FTTTGCSTDI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NLSTPYLEED | GTSMLVSCKK | CSVRVHASCY | GVPPAKASEE | WMCSRCSANA | LEEDCCLCSL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RGGALQRAND | DRWVHVSCAV | AILEARFVNI | AERSPVDVSK | IPLPRFKLKC | VFCKKRRKRN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AGCCVQCSHG | RCPTAFHVSC | AQAAGVMMQP | DDWPFVVFIT | CFRHKIPNLE | RAKGALLSIT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AGQKVISKHK | NGRFYQCEVV | RLTTETFYEV | NFDDGSFSDN | LYPEDIVSQD | CLQLGPPAEG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EVVQVRWTDG | QVYGAKFVAS | HPIQMYQVEF | EDGSQLVVKR | DDVYTLDEEL | PKRVKSRLSV |
| 1030 | 1040 | 1050 | 1060 | ||
| ASDMRFNEIF | TEKEVKQEKK | RQRVINSRYR | EDYIEPALYR | AIME |