Q8BRC6
Gene name |
Cfap91 |
Protein name |
Cilia- and flagella-associated protein 91 |
Names |
CFAP91, AMY-1-associating protein expressed in testis 1 homolog, AAT-1, MYCBP/AMY-1-associated testis-expressed protein 1, Protein MAATS1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320214 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BRC6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BRC6-F1 | Predicted | AlphaFoldDB |
48 variants for Q8BRC6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs230558499 | 12 | P>S | No | EVA | |
| rs216579270 | 23 | E>D | No | EVA | |
| rs254835027 | 35 | T>M | No | EVA | |
| rs3389410436 | 36 | Y>* | No | EVA | |
| rs212487142 | 97 | L>S | No | EVA | |
| rs46668976 | 128 | K>E | No | EVA | |
| rs3389418206 | 142 | Y>F | No | EVA | |
| rs3389407618 | 145 | F>L | No | EVA | |
| rs233682049 | 160 | V>F | No | EVA | |
| rs227882545 | 189 | A>G | No | EVA | |
| rs3406707690 | 192 | T>S | No | EVA | |
| rs3406854985 | 194 | Y>* | No | EVA | |
| rs3406920330 | 206 | P>A | No | EVA | |
| rs3406796575 | 206 | P>R | No | EVA | |
| rs247475777 | 222 | A>V | No | EVA | |
| rs3389418287 | 230 | L>I | No | EVA | |
| rs251871218 | 239 | I>M | No | EVA | |
| rs3389416971 | 242 | R>W | No | EVA | |
| rs3389364635 | 263 | E>K | No | EVA | |
| rs3389423781 | 265 | R>S | No | EVA | |
| rs3389407644 | 273 | E>V | No | EVA | |
| rs3389364689 | 295 | L>M | No | EVA | |
| rs3389364703 | 295 | L>W | No | EVA | |
| rs236628173 | 305 | D>N | No | EVA | |
| rs3389385780 | 338 | S>A | No | EVA | |
| rs3389425785 | 383 | N>K | No | EVA | |
| rs3389423769 | 388 | F>Y | No | EVA | |
| rs3389425850 | 390 | V>I | No | EVA | |
| rs3389432475 | 407 | S>T | No | EVA | |
| rs3389396764 | 419 | P>H | No | EVA | |
| rs260851081 | 424 | I>V | No | EVA | |
| rs3389418230 | 436 | A>V | No | EVA | |
| rs3389331960 | 447 | K>E | No | EVA | |
| rs3389414341 | 495 | V>M | No | EVA | |
| rs3389414287 | 510 | M>I | No | EVA | |
| rs232843899 | 547 | L>V | No | EVA | |
| rs3410333629 | 613 | E>D | No | EVA | |
| rs3389364690 | 620 | E>V | No | EVA | |
| rs227869742 | 622 | K>R | No | EVA | |
| rs3389364643 | 656 | R>* | No | EVA | |
| rs3389416950 | 657 | T>S | No | EVA | |
| rs3389423762 | 658 | A>V | No | EVA | |
| rs3389410477 | 688 | Q>H | No | EVA | |
| rs3389414297 | 695 | E>* | No | EVA | |
| rs227210242 | 745 | L>Q | No | EVA | |
| rs51954492 | 746 | Q>R | No | EVA | |
| rs245158619 | 760 | D>V | No | EVA | |
| rs3389410744 | 774 | I>K | No | EVA |
No associated diseases with Q8BRC6
1 regional properties for Q8BRC6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CFAP91 domain | 190 - 342 | IPR032840 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| axoneme | The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| axonemal central apparatus assembly | The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cilium movement | The directed, self-propelled movement of a cilium. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQTVTIQEP | RPNDQRIPYQ | CREVRRAKGG | FANRTYDYLY | DPLFIVSSER | DHAQANIQAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIRSRLKKVP | NFRSMFSNLF | HHPRYSMYWS | KTDPVPLHVT | REWRGQEAKH | KEVLRLQAAM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DTSFQMPKEK | DEDPDVSGKN | RYKFFDRPFL | PFLQQMPLNV | VLSPVKTQPL | LLTPESSKYA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IIPTKSTVAT | QTDYRDADVQ | TDPYSPEYVV | CQDTIPELLT | LANLTWGRGL | PAGQAEVEII |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERAREKRAWE | ATLPPLNDSV | QAEKRRKMMN | AMERKEWAFR | EGEIEKLQEL | RLEVLKQLLK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RREEDQNELN | MRHLNDQWYK | LQEAKEAKVA | QIRHKHVSDI | RKLMGKGKNI | EGKLQRRDII |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SDYSNFASQV | YGPLSRLGRF | PDNNSEDFVV | RNHYLNTYEG | LVELESSLPD | FVTQPRIKPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KPQIITTKAG | FLKRTARMDY | ELAEVHKALV | DKKNKGLEGT | KSLRFLQKNP | ISQARLPTPS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LEMTSYEEGE | IEMAVIYLQK | LLRGRVVQNM | MFEGKEKRLE | LILELRTSHA | LQEDDKLVKK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AEKQVTLALQ | RQRNLHEDKL | SVIENHLGDL | EGRVLADMFD | FLSKELVRLQ | EERRIHAFAM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LAERQRRMRE | AEESGRRQVE | QKRLQQEDMI | FKEVIKVHQS | TVTSYLEDII | LNTEERTAEE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QARKEIEKIA | EEINNIAYEM | ENRRTYLQSE | EIVAELVYSF | LIPEVQKDFV | KEKVRNAQRK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HILAAHEIIH | SNTETMLEEQ | VYKELQSEDF | ELEEEAESLD | SEVPTVSVSK | TSTIKPTQDE |
| GEG |