Q8BQP9

PR
Gene name
Rgs7bp (D13Bwg1146e, R7bp)
Protein name
Regulator of G-protein signaling 7-binding protein
Names
R7 family-binding protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:52882
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BQP9

Entry ID Method Resolution Chain Position Source
AF-Q8BQP9-F1 Predicted AlphaFoldDB

4 variants for Q8BQP9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389275764 160 G>* No EVA
rs3389297820 160 G>E* No EVA
rs3389285312 174 E>V No EVA
rs3389275780 185 P>L No EVA

No associated diseases with Q8BQP9

No regional properties for Q8BQP9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8BQP9

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cell membrane ; Lipid-anchor
  • Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation (PubMed:15897264, PubMed:21343290)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
anchored component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
anchored component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
dendritic spine head Distal part of the dendritic spine, that carries the post-synaptic density.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynapse The part of a synapse that is part of the post-synaptic cell.
presynapse The part of a synapse that is part of the presynaptic cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
regulation of postsynaptic membrane potential Any process that modulates the potential difference across a post-synaptic membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSAPNGRKK RPSRSTRSSI FQISKPPLQS GDWERRGSGS ESAHKTQRAL DDCKMLVQEF
70 80 90 100 110 120
NTQVALYREL VISIGDVSVS CPSLRAEMHK TRTKGCEMAR QAHQKLAAIS GPEDGEIHPE
130 140 150 160 170 180
ICRLYIQLQC CLEMYTTEML KSICLLGSLQ FHRKGKEASG GAKNLDSKIE ENAETPALED
190 200 210 220 230 240
SLSSPLESQQ QCWQVATDIE NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPM
250
VRRRKRRFFG LCCLVSS