Q8BQB4

PR
Gene name
Fjx1
Protein name
Four-jointed box protein 1
Names
Four-jointed protein x1, Four-jointed protein homolog
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14221
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

338-363 (Activation loop from InterPro)

Target domain

146-430 (C-terminal kinase domain of Drosophila Four-jointed, Fj,, mouse Fjx1, and related proteins)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8BQB4

Entry ID Method Resolution Chain Position Source
AF-Q8BQB4-F1 Predicted AlphaFoldDB

3 variants for Q8BQB4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3391990161 188 I>V No EVA
rs3391828381 348 R>P No EVA
rs236764676 379 H>R No EVA

No associated diseases with Q8BQB4

1 regional properties for Q8BQB4

Type Name Position InterPro Accession
domain Band 7 domain 6 - 269 IPR001107

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
retina layer formation The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86VR8 FJX1 Four-jointed box protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MGRKMRGAAA AAGLWLLALS SLLTLWGGLL PPRTELPASR PPEDRLPPHP IQSGGPAPEP
70 80 90 100 110 120
RFPLPPPLVW DARGGSLKTF RALLTLAAGA DNPPRRHQDD RGRHEPSGLS WPEERRAVHG
130 140 150 160 170 180
GVFWSRGLEE QVPRGFSEAQ AAAWLEVARG ARVVALDRGG CGRSSNRLAR FADGTRACVR
190 200 210 220 230 240
YGINPEQIQG EALSYYLARL LGLQRHVPPL ALARVEARGA QWVQVQEELR TAHWTEGSVV
250 260 270 280 290 300
SLTRWLPNLT DVVVPEPWRS EDGRLRPLRD AGGELTNLSQ AELVDLVQWT DLILFDYLTA
310 320 330 340 350 360
NFDRLVSNLF SLQWDPRVMH RATSNLHRGP GGALVFLDNE AGLVHGYRVA GMWDKYNEPL
370 380 390 400 410 420
LQSVCVFRER TARRVLELHR GQDAAARLLR LYSRHEPRFP ELAELSEPHA QLLQRRLDFL
430 440
AKHILHCKAK YGRRPGDLIT LRGREGLGYE