Q8BMI0
PR
Gene name |
Fbxo38 |
Protein name |
F-box only protein 38 |
Names |
Modulator of KLF7 activity, MoKA |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:107035 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BMI0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BMI0-F1 | Predicted | AlphaFoldDB |
46 variants for Q8BMI0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389500758 | 11 | C>* | No | EVA | |
| rs3389485197 | 27 | K>* | No | EVA | |
| rs3389500188 | 35 | H>Y | No | EVA | |
| rs3389515254 | 72 | R>I | No | EVA | |
| rs3389500785 | 123 | Q>L | No | EVA | |
| rs3389500191 | 144 | V>I | No | EVA | |
| rs3389522233 | 220 | L>I | No | EVA | |
| rs3389454330 | 235 | R>* | No | EVA | |
| rs3389506415 | 300 | L>I | No | EVA | |
| rs3389500265 | 361 | F>L | No | EVA | |
| rs3389517949 | 364 | Q>* | No | EVA | |
| rs3389500789 | 371 | D>Y | No | EVA | |
| rs3389473274 | 372 | L>M | No | EVA | |
| rs3389473256 | 378 | A>G | No | EVA | |
| rs3389454345 | 388 | T>N | No | EVA | |
| rs3389485146 | 497 | D>H | No | EVA | |
| rs3389485176 | 515 | H>Y | No | EVA | |
| rs3389515255 | 546 | E>* | No | EVA | |
| rs3389522228 | 546 | E>G | No | EVA | |
| rs3389454321 | 547 | D>E | No | EVA | |
| rs3389506573 | 547 | D>V | No | EVA | |
| rs3389485173 | 550 | Q>E | No | EVA | |
| rs3389506578 | 551 | E>V | No | EVA | |
| rs3389500217 | 552 | D>V | No | EVA | |
| rs3408268335 | 649 | L>H | No | EVA | |
| rs225142558 | 658 | Q>H | No | EVA | |
| rs36884937 | 659 | T>M | No | EVA | |
| rs3389471778 | 691 | R>K | No | EVA | |
| rs49824932 | 715 | A>T | No | EVA | |
| rs215344650 | 721 | A>T | No | EVA | |
| rs257723066 | 729 | Q>E | No | EVA | |
| rs234254097 | 734 | A>V | No | EVA | |
| rs234997744 | 757 | V>A | No | EVA | |
| rs3389506927 | 762 | G>E | No | EVA | |
| rs3389506626 | 764 | E>G | No | EVA | |
| rs586113448 | 771 | E>K | No | EVA | |
| rs3389506956 | 781 | R>* | No | EVA | |
| rs244558007 | 795 | G>D | No | EVA | |
| rs3389471775 | 802 | R>L | No | EVA | |
| rs3389515215 | 852 | R>M | No | EVA | |
| rs3389500764 | 889 | E>D | No | EVA | |
| rs3389500251 | 995 | Q>P | No | EVA | |
| rs3408697402 | 1066 | I>F | No | EVA | |
| rs3389500200 | 1115 | R>T | No | EVA | |
| rs3408268352 | 1166 | M>V | No | EVA | |
| rs3389522218 | 1195 | I>L | No | EVA |
No associated diseases with Q8BMI0
1 regional properties for Q8BMI0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | F-box domain | 32 - 64 | IPR001810 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| adaptive immune response | An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of T cell mediated immune response to tumor cell | Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell. |
| protein K48-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6PIJ6 | FBXO38 | F-box only protein 38 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPRKKSAKV | CVMDSEVAEE | MTADEEKDYM | NQLSHEVLCH | IFRYLPLQDI | MCMECLSRKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEAVTLYLRV | VRVVDLCAGR | WWEYMPSGFT | DSSFLTLLKK | MPDVEQLYGL | HPRYLERRRV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGQEAFSIPG | VLEALQACPN | LVGVETSHLE | LVESIWTYMP | HVHILGKFRN | RNGAFPIPPE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKLKIPIGAK | IQTLHLVGVN | VPEIPCIPML | RHLYMKWVRL | TKPQPFKDFL | CISLRTFVMR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NCAGPTNSLK | YVPLVTGLAS | ARNLEHLEMV | RVPFLGGLIQ | HVVEDSWRSG | GFRNLHTIVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GACKNALEVD | LGYLIITAAR | RLHEVRIQPS | LTKDGVFSAL | KMAELEFPQF | ETLHLGYVDE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLLQSRMANA | DLVKYGLADV | VENPGIITDI | GMKAVNEVFS | CIKYLAIYNC | PHLHNPYNWI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SDHSRWMRLV | DINLVRCHAL | KLDSFGQFVE | LLPSLEFISL | DQMFREPPKG | CARVGLSAGT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GIGVSSALVS | NQNSNNDNDN | NAPNNNANLH | DNNHHHPDDS | DDDNDFRPDL | QAGEAQFAAD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ALNEMEDMVQ | EDGELVAESG | NGMPAHNREV | LPVDADEEQA | GPSGLQRVVK | PTPIADHDSE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SDDEEDSLEL | QEVWAPKNGT | RRYSEREEKT | GDSGQSRETA | VSGKGKTPLR | KRCNNSHQTG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QAKPFPLEES | SCEKGCQVTS | EQIKADMKAA | RDVSEKKKSK | DVYPSCSSSS | SSTAASTAGN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ASSPSTASQS | PDFARTVTSS | GSSEPSPPEV | DVSRQCVCSP | GGSEDSEAME | EGDAESSVCP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RCCCLRPQES | QRRTGRCSDE | ERPSTSRACV | VNGADGTRSA | FSFRTLPQGG | SSGPAHDERT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NGSGCGATGE | DRRGSSQPES | CDVQSNEDYP | RRPLTRARSR | LSHVPLISES | EVAKTKPCHA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| MKRKRTADKS | TSTSDPVIED | DHVQVLVLKS | KNLVGVTMTN | CGITDLVLKD | CPKMMFIHAT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RCRVLKHLKV | ENAPIVNRFD | YAQCKKLNMD | QVLDQILRMP | PERNRIIYLR | PMQQVDTLTL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EQKLFSGPYP | YHICIIHEFS | NPPNVRNKVR | IRNWMDTIAN | INQELIKYEF | FLEATRTEED |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LKKYPKYPWG | REIYTLEGVV | DGAPYSMISD | FPWLRSLRTA | EPNSFARYDF | EDDEESTIYA |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| PRRKGQLSAD | ICMETIGEEI | SEMRQMKRGI | FQRVVAIFIH | YCDVNGEPVE | DDYI |