AiPD: Autoinhibited Protein Database

Gene name	Gtf3c2 (Kiaa0011)
Protein name	General transcription factor 3C polypeptide 2
Names	TF3C-beta, Transcription factor IIIC 110 kDa subunit, TFIIIC 110 kDa subunit, TFIIIC110, Transcription factor IIIC subunit beta
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71752
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-314 (Predicted disordered autoinhibitory region) PR

1-314 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BL74-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388744794	13	E>D	No	EVA
rs3388752715	14	A>S	No	EVA
rs265185802	46	A>T	No	EVA
rs3388757950	168	R>M	No	EVA
rs3388737156	169	P>H	No	EVA
rs3388749301	188	V>M	No	EVA
rs216624691	361	I>L	No	EVA
rs3395238255	378	A>RPEPRVVPL*	No	EVA
rs3394763264	381	E>S	No	EVA
rs3388752733	402	P>H	No	EVA
rs3395404837	434	L>Q	No	EVA
rs3388751890	458	G>E	No	EVA
rs3388748863	461	C>Y	No	EVA
rs3395238272	474	S>T	No	EVA
rs3388754427	475	G>W	No	EVA
rs3388748852	476	A>G	No	EVA
rs3388744781	538	Q>H	No	EVA
rs3388741889	575	M>K	No	EVA
rs3388749266	593	S>F	No	EVA
rs3388752053	612	V>I	No	EVA
rs3388752483	647	N>D	No	EVA
rs3388757987	661	L>P	No	EVA
rs3388723844	694	A>V	No	EVA
rs3388752698	697	T>A	No	EVA
rs3388749335	713	L>I	No	EVA
rs3388754431	720	D>V	No	EVA
rs3388749378	725	L>I	No	EVA
rs3388741903	738	I>N	No	EVA
rs3388751917	752	K>E	No	EVA
rs3388744776	770	T>I	No	EVA
rs3388752454	774	T>N	No	EVA
rs3388745113	777	P>H	No	EVA
rs3388752703	782	T>I	No	EVA
rs3388737118	797	T>I	No	EVA
rs3388723815	832	A>D	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	452 - 508	IPR001680-1
repeat	WD40 repeat	530 - 580	IPR001680-2
repeat	WD40 repeat	598 - 640	IPR001680-3
repeat	WD40 repeat	821 - 861	IPR001680-4
conserved_site	WD40 repeat, conserved site	625 - 639	IPR019775

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
transcription factor TFIIIC complex	A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
RNA polymerase III general transcription initiation factor activity	A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.

Name	Definition
transcription by RNA polymerase III	The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8WUA4	GTF3C2	General transcription factor 3C polypeptide 2	Homo sapiens (Human)	PR