AiPD: Autoinhibited Protein Database

Gene name	Gcfc2 (Gcf, Tcf9)
Protein name	Intron Large complex component GCFC2
Names	GC-rich sequence DNA-binding factor, GC-rich sequence DNA-binding factor 2, Transcription factor 9, TCF-9
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:330361
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

138-212 (Predicted disordered autoinhibitory region) PR

138-212 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BKT3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs263544686	31	A>V	No	EVA
rs231998321	36	S>F	No	EVA
rs46104730	78	E>G	No	EVA
rs47202625	86	T>A	No	EVA
rs864286785	90	E>G	No	EVA
rs265436553	93	H>Y	No	EVA
rs48892714	95	L>S	No	EVA
rs249731457	97	G>E	No	EVA
rs3388804604	104	P>S	No	EVA
rs46947067	115	R>K	No	EVA
rs51547188	117	V>L	No	EVA
rs3388837878	121	V>D	No	EVA
rs248504332	122	E>K	No	EVA
rs3388804549	171	P>L	No	EVA
rs3388832383	177	R>K	No	EVA
rs3388824189	213	D>N	No	EVA
rs585294970	226	I>M	No	EVA
rs579903464	228	A>V	No	EVA
rs240851877	242	T>I	No	EVA
rs3388837518	292	S>P	No	EVA
rs36393362	347	R>W	No	EVA
rs231876289	384	D>N	No	EVA
rs251661814	392	E>K	No	EVA
rs3388838823	406	E>D	No	EVA
rs37753575	411	C>F	No	EVA
rs236001589	411	C>R	No	EVA
rs38093098	418	S>A	No	EVA
rs3388831994	422	E>K	No	EVA
rs3388841451	426	A>S	No	EVA
rs36743061	433	K>T	No	EVA
rs3388832396	447	E>D	No	EVA
rs3388838852	486	L>P	No	EVA
rs3388820134	507	G>S	No	EVA
rs225604218	522	E>G	No	EVA
rs30934856	526	D>E	No	EVA
rs237180658	540	A>S	No	EVA
rs3388844005	546	T>A	No	EVA
rs251565172	557	T>I	No	EVA
rs3388837908	578	F>I	No	EVA
rs3388837474	578	F>Y	No	EVA
rs3388835830	652	L>I	No	EVA
rs30808424	677	A>T	No	EVA
rs232788362	678	V>I	No	EVA
rs247322527	680	G>E	No	EVA
rs3388840239	690	I>K	No	EVA
rs3388837496	710	Q>K	No	EVA
rs3388832374	713	N>D	No	EVA
rs3396966488	714	F>L	No	EVA
rs3396989806	715	I>M	No	EVA
rs3412852117	715	I>N	No	EVA
rs257837264	757	R>H	No	EVA
rs222126958	763	P>T	No	EVA
rs4226016	766	S>N	No	EVA
rs3388831973	770	V>R	No	EVA

Type	Name	Position	InterPro Accession
domain	GCF, C-terminal	457 - 670	IPR022783

		Description
EC Number
Subcellular Localization	Nucleus, nucleoplasm Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
U2-type post-mRNA release spliceosomal complex	A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Name	Definition
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
spliceosomal complex assembly	The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y5B6	PAXBP1	PAX3- and PAX7-binding protein 1	Homo sapiens (Human)	PR
P16383	GCFC2	Intron Large complex component GCFC2	Homo sapiens (Human)	PR