Q8BKN5
PR
Gene name |
Tubgcp5 (Kiaa1899) |
Protein name |
Gamma-tubulin complex component 5 |
Names |
GCP-5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:233276 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BKN5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BKN5-F1 | Predicted | AlphaFoldDB |
36 variants for Q8BKN5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs6389479 | 7 | S>F | No | EVA | |
| rs31144998 | 9 | S>I | No | EVA | |
| rs31514721 | 9 | S>R | No | EVA | |
| rs3388902972 | 61 | V>L | No | EVA | |
| rs3397933340 | 94 | A>T | No | EVA | |
| rs3388905907 | 139 | D>E | No | EVA | |
| rs3388916845 | 151 | E>Q | No | EVA | |
| rs3388903035 | 181 | D>E | No | EVA | |
| rs3388902993 | 182 | S>Y | No | EVA | |
| rs3388892683 | 184 | I>L | No | EVA | |
| rs3397791689 | 201 | G>VLLF* | No | EVA | |
| rs3397696053 | 204 | V>G | No | EVA | |
| rs3397910343 | 206 | W>C | No | EVA | |
| rs3388908390 | 211 | D>Y | No | EVA | |
| rs3388916307 | 233 | P>S | No | EVA | |
| rs3388913779 | 235 | S>T | No | EVA | |
| rs3388908440 | 269 | Q>H | No | EVA | |
| rs3398090217 | 297 | R>S | No | EVA | |
| rs3398090244 | 298 | N>Y | No | EVA | |
| rs3397166158 | 300 | I>N | No | EVA | |
| rs3388914058 | 314 | L>M | No | EVA | |
| rs261474164 | 342 | L>P | No | EVA | |
| rs228777836 | 344 | P>L | No | EVA | |
| rs3388916334 | 377 | E>V | No | EVA | |
| rs3388908356 | 438 | N>H | No | EVA | |
| rs3388914096 | 608 | E>D | No | EVA | |
| rs265812112 | 612 | P>A | No | EVA | |
| rs265812112 | 612 | P>T | No | EVA | |
| rs3412941790 | 751 | T>A | No | EVA | |
| rs3388916326 | 751 | T>S | No | EVA | |
| rs242401516 | 787 | T>S | No | EVA | |
| rs3388892670 | 797 | D>Y | No | EVA | |
| rs3388908414 | 907 | H>Y | No | EVA | |
| rs3388908412 | 950 | V>M | No | EVA | |
| rs3388908435 | 954 | I>M | No | EVA | |
| rs3388892715 | 987 | F>L | No | EVA |
No associated diseases with Q8BKN5
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| equatorial microtubule organizing center | A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis. |
| gamma-tubulin complex | A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. |
| gamma-tubulin large complex | A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| gamma-tubulin binding | Binding to the microtubule constituent protein gamma-tubulin. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| microtubule nucleation | The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96RT8 | TUBGCP5 | Gamma-tubulin complex component 5 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARPKSSGSR | MDRQLEHDVC | ELVRQVTGLQ | DEADPNFQLA | LDFVWSNFRF | HRFLDVNSHK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VEKTIEGIYE | KFTIHSDLNK | AASWKRLTKE | FLNASLPSTE | KIKTDAHYSI | LSLLLCLSDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSNSNYVETP | REKEVEKKDD | FDWGKYLMEG | EEIGLGPNID | TPNWSEDSDD | EDAQQPLSRE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSGIQVDRTP | LEEQDHNRKG | GPQVCWEDEP | DSRSWLEQHV | VHQYWTTRRF | RIPHSAHLHS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLAAVWDQHL | YSSDPLYVPD | DRVVVTETQV | IRETLWLLSG | VKKMFIFQLI | DGKVTVRNNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IVTHLTHSCL | RSVLEQIAAY | GQVVFRLQEF | IDEVMGHSSE | SLPPGNGPIP | KKQPDAPFRT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQAFMWALYK | YFINFKEELT | DIEKCVISSD | TTITLAIVVN | KLAPRLAQLK | VLDKVFSTGV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AEVPPDTRNV | VRASHLLNTL | YKAILEYDNV | GEASEQTVSL | LFSLWVETVR | PYLQTVDEWI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VHGHLWDGAR | EFIIQRNKNV | PVNHRDFWYA | TYTLYSVSEK | TENEDKVSDS | ASASSGSDQG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PSSRQHTMVS | FLKPVLKQII | MAGKSMQLLK | NLNCAEGPAC | QAAARDAERK | SLYTLFLESI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLRLQHGEDS | APHIVNEDQT | TKENLIKMQS | IAERHLELDD | IHDPLLAINF | ARLYLEQSDF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HEKFAGGDIC | VDRSSESVTC | QTFELTLRSC | LYPHIDKQYL | HCCGNLMQTL | KRDFRLVEYL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QAMRNFFLME | GGDTMYDFYT | SIFDKIREKE | TWQNVSFLNV | QLQEAVGQRY | PEDSLRLSIS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FENVDTTKKK | LPVHILDGLT | LSYKVPWPVD | IVISVECQKI | YNQVFLLLLQ | IKWAKYSLDV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LLFGELGNAA | ERSQAKEDIP | RDQDTPSQFG | PPKESLRQQI | HRMFLLRVKL | MHFVNSLHNY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IMTRILHSTG | LEFQHQVEEA | KDLDQLIKIH | YRYLSTIHDR | CLLREKVSFV | KEAIMKVLNL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ALMFAEGWQA | GLGAWQMESI | EKMESDFKNC | HMFLVTILNK | AVCRGSFPHL | ESLALSLMAG |
| MEQS |