Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BI79
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BI79-F1 | Predicted | AlphaFoldDB |
No variants for Q8BI79
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8BI79 | |||||
No associated diseases with Q8BI79
No regional properties for Q8BI79
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BI79 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| axoneme | The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| axonemal dynein complex assembly | The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. |
| axoneme assembly | The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
| cilium movement | The directed, self-propelled movement of a cilium. |
| determination of digestive tract left/right asymmetry | Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed. |
| determination of left/right symmetry | The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. |
| determination of liver left/right asymmetry | Determination of the asymmetric location of the liver with respect to the left and right halves of the organism. |
| determination of pancreatic left/right asymmetry | Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism. |
| epithelial cilium movement involved in determination of left/right asymmetry | The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves. |
| epithelial cilium movement involved in extracellular fluid movement | The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid. |
| flagellated sperm motility | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. |
| heart looping | The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. |
| inner dynein arm assembly | The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. |
| lung development | The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. |
| motile cilium assembly | The aggregation, arrangement and bonding together of a set of components to form a motile cilium. |
| protein localization to cilium | A process in which a protein is transported to, or maintained in, a location within a cilium. |
| regulation of cilium beat frequency | Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMDAEKVSTD | GEAISEGEVG | SNGETPPETE | VEFIGETAPD | TDVEFIGETS | PGTDVEPTGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SIQETEVESI | GEATPGMDVE | PIKKTMTELN | VESIGEETSE | TDVDSIRKAL | RGIDLESITV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AYPPKKAKHR | KVRPQAEVES | TGRAAPEGEL | EVSDHEKVEA | LLDELDELSE | IVSSPEVSYS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DISPLEMGED | DTNVSATSTD | TFQQGIYEPI | EPIEPTEPPE | PAEPPKPAET | PEDSTVRAPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HPYQRDFPMG | ARHRFRLSIM | GSLTPSDTDD | LPLETDEPPQ | QESVQSTPRA | LEETRIQFLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QVQSLSPEAL | LDRATEGSDE | AEEEGSQLIV | LDPDHPLMIR | FQEALKGYLN | RQMDKLKLDV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QELDVATKQT | RSQRQELGVN | LYGVQQHLAR | LQMQLEKSHD | RHSLVACERR | RKEEELQCAR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SVYNKTCQTA | NEERKKLAAL | QTEVESLALH | LFYMQNIEQD | VRDDIQVMKQ | VVRKTETEKM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HAEVEKKKQD | LFVDQLTERS | HQLEENIALF | EAQYLSQAED | TRVLKKAVTE | AITEIDTIAV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EKKRILQQWT | TSLVGMKHRN | EAYKTVMDAL | RECQHQVKST | DSEIEVCKKS | IMQEEEKNEK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LARLLNRAET | EATLVQKMTA | QCLSKQEALQ | TEFNTYQLAL | QDTEEMLNKG | YVEHSAVLSE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LQATRQAFHQ | EQELRQKMDM | SMVDKLQEQG | TSSKMTKYFH | QLLRKLQKEN | TNLVTHLSKI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DGDIAQATLD | ITNTNCKIDM | HKKTLAEMDK | EVKRFNDLIT | NSESEIARRT | ILIERKQSLI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NFFNKQLEQM | VSELGGEEAG | PLELEIKRLS | KLTEEYNTGV | AEAQMTWLRL | QQELVQVTHE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| REEQLVSVDQ | LKKEVHIMEQ | KKLRIESKIA | HEKKEQKIVS | RHMRDLDNDL | SKLNMLLDKN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RCSSEELEQN | NIATETEFLR | TLKDSERETI | QMQEKLMELS | EEKATLLNSF | MEAEHQIMLW |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EKKIQLAKEM | RSSVDSETGQ | TEIRAMKAEI | HRMKVRHGQL | LKQQEKMIRD | MELAVARRET |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IVVQAEGQSK | IDKKVITKTE | FHYQQRELQK | KVREMHKATD | DCTNTISELE | ETQKFLSSSL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| QEKQQLLSEM | QATTDVLEEE | INQLTALKRQ | NLLEIVTLQT | RGKHLQAAIE | GKYVFLHRNS |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| RSQLMERKRL | SVRLSQLNKV | LSSVQEDYPQ | YQEVLQSIQQ | KIATKLETPE | PS |