AiPD: Autoinhibited Protein Database

Gene name	Pgs1 (Saf)
Protein name	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
Names	Phosphatidylglycerophosphate synthase 1, PGP synthase 1, Silencer-associated factor
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74451
EC number	2.7.8.5: Transferases for other substituted phosphate groups
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

9-91 (Predicted disordered autoinhibitory region) PR

9-91 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BHF7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389221282	54	L>*	No	EVA
rs3389195832	54	L>F	No	EVA
rs3389221677	55	L>Q	No	EVA
rs3389216414	68	C>S	No	EVA
rs3389236184	70	C>Y	No	EVA
rs3389221654	71	P>S	No	EVA
rs13473066	113	I>T	No	EVA
rs3389231010	192	F>L	No	EVA
rs3389191184	213	I>L	No	EVA
rs3389191170	213	I>T	No	EVA
rs3389224009	325	S>I	No	EVA
rs13473068	371	T>M	No	EVA
rs3389236095	375	R>H	No	EVA
rs3389195767	379	V>F	No	EVA
rs3389218676	391	A>V	No	EVA
rs3389218713	399	T>S	No	EVA
rs3389218704	409	S>P	No	EVA
rs3389230999	442	S>N	No	EVA
rs3389224029	472	G>W	No	EVA
rs3389195840	541	W>*	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8BHF7

		Description
EC Number	2.7.8.5	Transferases for other substituted phosphate groups
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
organelle membrane	A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+).

Name	Definition
cardiolipin biosynthetic process	The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
diacylglycerol metabolic process	The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
phosphatidylglycerol biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol.
phospholipid biosynthetic process	The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins