Q8BHB4
PR
Gene name |
Wdr3 |
Protein name |
WD repeat-containing protein 3 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:269470 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BHB4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BHB4-F1 | Predicted | AlphaFoldDB |
53 variants for Q8BHB4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388649563 | 21 | S>I | No | EVA | |
| rs3388634210 | 39 | V>M | No | EVA | |
| rs242147906 | 64 | N>I | No | EVA | |
| rs3388647162 | 142 | L>V | No | EVA | |
| rs3388647562 | 152 | V>L | No | EVA | |
| rs250017389 | 159 | R>Q | No | EVA | |
| rs3388634241 | 182 | H>Q | No | EVA | |
| rs3388656959 | 199 | L>Q | No | EVA | |
| rs214547574 | 221 | D>A | No | EVA | |
| rs3388654187 | 221 | D>N | No | EVA | |
| rs243055606 | 243 | I>T | No | EVA | |
| rs3388647219 | 260 | K>N | No | EVA | |
| rs33325741 | 269 | S>R | No | EVA | |
| rs3388652678 | 274 | I>V | No | EVA | |
| rs3388656358 | 277 | E>D | No | EVA | |
| rs3388641659 | 286 | A>T | No | EVA | |
| rs30512224 | 287 | V>M | No | EVA | |
| rs3388650948 | 301 | S>A | No | EVA | |
| rs3388649551 | 303 | L>I | No | EVA | |
| rs3388656875 | 335 | N>D | No | EVA | |
| rs3388653558 | 336 | E>VSDG* | No | EVA | |
| rs3388649590 | 338 | E>G | No | EVA | |
| rs3388647189 | 355 | V>I | No | EVA | |
| rs3388649072 | 373 | P>A | No | EVA | |
| rs3388641675 | 388 | V>A | No | EVA | |
| rs3388656297 | 401 | Q>* | No | EVA | |
| rs578797839 | 418 | R>G | No | EVA | |
| rs3388641634 | 523 | D>H | No | EVA | |
| rs3388652657 | 536 | R>SE* | No | EVA | |
| rs3388647589 | 557 | S>A | No | EVA | |
| rs3388634166 | 559 | N>Y | No | EVA | |
| rs3388647221 | 570 | C>S | No | EVA | |
| rs233573654 | 579 | T>S | No | EVA | |
| rs3388656914 | 633 | D>G | No | EVA | |
| rs33323287 | 650 | A>T | No | EVA | |
| rs3388645477 | 655 | K>N | No | EVA | |
| rs33323284 | 663 | K>N | No | EVA | |
| rs242169979 | 726 | V>M | No | EVA | |
| rs33321362 | 733 | A>T | No | EVA | |
| rs3388653516 | 762 | A>G | No | EVA | |
| rs230881927 | 781 | K>R | No | EVA | |
| rs255775012 | 794 | I>V | No | EVA | |
| rs237314154 | 805 | A>T | No | EVA | |
| rs3388656298 | 811 | F>L | No | EVA | |
| rs264502861 | 846 | L>S | No | EVA | |
| rs3388649110 | 875 | V>M | No | EVA | |
| rs3388649074 | 900 | G>D | No | EVA | |
| rs3388649103 | 909 | E>D | No | EVA | |
| rs3393514835 | 915 | M>I | No | EVA | |
| rs3393409243 | 915 | M>V | No | EVA | |
| rs3388649117 | 916 | F>L | No | EVA | |
| rs3388652285 | 922 | S>R | No | EVA | |
| rs30152485 | 929 | K>R | No | EVA |
No associated diseases with Q8BHB4
11 regional properties for Q8BHB4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 54 - 228 | IPR001680-1 |
| repeat | WD40 repeat | 403 - 481 | IPR001680-2 |
| repeat | WD40 repeat | 484 - 525 | IPR001680-3 |
| repeat | WD40 repeat | 538 - 576 | IPR001680-4 |
| repeat | WD40 repeat | 579 - 702 | IPR001680-5 |
| domain | Small-subunit processome, Utp12 | 805 - 905 | IPR007148 |
| conserved_site | WD40 repeat, conserved site | 122 - 136 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 206 - 220 | IPR019775-2 |
| repeat | G-protein beta WD-40 repeat | 122 - 136 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 605 - 619 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 689 - 703 | IPR020472-3 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| Pwp2p-containing subcomplex of 90S preribosome | A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| snoRNA binding | Binding to a small nucleolar RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UNX4 | WDR3 | WD repeat-containing protein 3 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLTKQYLRY | VASAVFGLIG | SQKGNIVFVT | LRGEKGRYVA | VPACEHVFIW | DLRKGEKILI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQGNKQEVTC | LCPSPDGLHL | AVGYEDGAIR | IFSLLSGEGN | ITFNGHKAAV | TSLKYDQLGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLASGSKDTD | VIIWDVINES | GLYRLKGHKD | AVTQALFLRE | RNLLVTSGKD | TMVKWWDLDN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QHCFKTMVGH | RTEVWGLVLV | SEEKRLITGA | ADSELRAWDI | DYLQEIDDPE | EPEPKKIKEC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGIQDTPESE | DSTLEADDEK | SEDRILSCSK | AGSIMREGRD | RVVNLAVDKT | GRILACHGTD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVLEVFCILS | KAEVQKKMDK | KLKKARKKAR | LNSANEEEDP | ETSVSMTLQD | EILRVAKIKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SAKIKSFDLI | HSPQGELKAV | FLLQNNLVEL | YSLNASLPAP | QPVRTSRITI | GGHRSDVRTL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFSSDNIAVL | SAAADSIKIW | NRSTLQCIRT | MPCEYALCSF | FVPGDRQVVI | GTKTGNLQLY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLASGTLLET | IAAHDGALWS | MSLSPDQRGF | VTGGADKAVK | FWDFELVTDK | NSTQKRLSVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QTRTLQLDED | VLCVSYSPNQ | KLLAVSLLDC | TVKVFYVDTL | KFFLSLYGHK | LPVLCMDISH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DGALIATGSA | DRNVKIWGLD | FGDCHRSLFA | HDDSVMYLRF | VPKSHLFFTA | GKDHKIKQWD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ADKFEHIQTL | EGHHQEIWCL | AVSPSGDYVV | SASHDKSLRL | WERTREPLIL | EEEREMQREA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EYEESVAKED | QPAVPGETQG | DNYFTGKKTI | ETVKAAERIM | EAIELHREET | AKMKEHRAIC |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KAAGKEVPLP | VNPILMAHGN | ISPSAYVLET | FKGIRSSELE | EALLVLPFSY | VPDVLTLFNE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FIQTGLDVEL | LCRCLFFLLR | IHFGQITSNQ | MLVPVIEKLK | ETTISKVRQV | QDAIGFNMAG |
| 910 | 920 | 930 | 940 | ||
| LDYLKRECEA | KSEVMFFAEA | TSHLEEKKKK | RKNRKRMILT | LT |