Q8BGF7
PR
Gene name |
Pan2 |
Protein name |
PAN2-PAN3 deadenylation complex catalytic subunit Pan2 |
Names |
Inactive ubiquitin carboxyl-terminal hydrolase 52, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:103135 |
EC number |
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BGF7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BGF7-F1 | Predicted | AlphaFoldDB |
50 variants for Q8BGF7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389137510 | 17 | M>I | No | EVA | |
| rs3389140038 | 23 | P>L | No | EVA | |
| rs3401560523 | 31 | P>HSVANLDSGGHPGLGPG* | No | EVA | |
| rs248914054 | 33 | L>M | No | EVA | |
| rs248544392 | 133 | T>S | No | EVA | |
| rs3389133095 | 137 | L>F | No | EVA | |
| rs36862080 | 161 | V>L | No | EVA | |
| rs3389122500 | 162 | L>F | No | EVA | |
| rs3389111019 | 205 | T>S | No | EVA | |
| rs3389135922 | 209 | F>L | No | EVA | |
| rs3389140011 | 246 | G>S | No | EVA | |
| rs3389144340 | 254 | F>I | No | EVA | |
| rs3389133262 | 274 | M>I | No | EVA | |
| rs3389139995 | 287 | P>Q | No | EVA | |
| rs3389145212 | 352 | G>A | No | EVA | |
| rs3389106286 | 426 | V>M | No | EVA | |
| rs3389127410 | 447 | R>L | No | EVA | |
| rs3401560519 | 451 | R>S | No | EVA | |
| rs3389131154 | 478 | R>* | No | EVA | |
| rs3400580804 | 547 | H>L | No | EVA | |
| rs3401679248 | 552 | E>G | No | EVA | |
| rs3389133064 | 685 | P>R | No | EVA | |
| rs248137135 | 706 | E>D | No | EVA | |
| rs3389073036 | 716 | C>S | No | EVA | |
| rs3389127425 | 728 | I>F | No | EVA | |
| rs3401875423 | 818 | C>F | No | EVA | |
| rs3402035690 | 821 | A>S | No | EVA | |
| rs29318900 | 822 | D>E | No | EVA | |
| rs3389127438 | 833 | S>A | No | EVA | |
| rs3401833632 | 838 | A>* | No | EVA | |
| rs230005407 | 844 | L>H | No | EVA | |
| rs3389145256 | 866 | S>N | No | EVA | |
| rs3389145233 | 874 | G>C | No | EVA | |
| rs3389139967 | 895 | F>L | No | EVA | |
| rs259288813 | 962 | L>M | No | EVA | |
| rs3389133269 | 968 | P>S | No | EVA | |
| rs3389133986 | 969 | Q>* | No | EVA | |
| rs3389140042 | 971 | G>A | No | EVA | |
| rs3389145214 | 971 | G>R | No | EVA | |
| rs3389144413 | 1072 | I>F | No | EVA | |
| rs3389133984 | 1096 | K>M | No | EVA | |
| rs233791537 | 1107 | H>Q | No | EVA | |
| rs3389146634 | 1107 | H>Y | No | EVA | |
| rs228385379 | 1135 | S>R | No | EVA | |
| rs3389133089 | 1149 | Y>F | No | EVA | |
| rs3389131158 | 1161 | S>P | No | EVA | |
| rs3389136005 | 1169 | L>I | No | EVA | |
| rs3389133063 | 1177 | D>V | No | EVA | |
| rs3389131155 | 1188 | S>N | No | EVA | |
| rs3389137549 | 1196 | S>L | No | EVA |
No associated diseases with Q8BGF7
No regional properties for Q8BGF7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BGF7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.13.4 | Exoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
| PAN complex | A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| metal ion binding | Binding to a metal ion. |
| nucleic acid binding | Binding to a nucleic acid. |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| nuclear-transcribed mRNA catabolic process, exonucleolytic | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. |
| nuclear-transcribed mRNA poly(A) tail shortening | Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. |
| positive regulation of cytoplasmic mRNA processing body assembly | Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q504Q3 | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNFEGLDPGL | AEFSPAMHST | LDPVLDAHLN | PSLLQNVELD | PEGVALEALP | VQESVHIMEG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VYSELHSVVA | EVGVPVSVSH | FDLHEEMLWV | GSHGGHATSF | FGPALERYSS | FQVNGGDDIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QIQSLENGIL | FLTKNNLKYM | ARGGLIIFDY | LLDENEDMHS | VLLTDNSTLL | VGGLQNHVLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDLNTVQETQ | KYAVETPGVT | IMRQTNRFFF | CGHTSGKVSL | RDLRSFKVEH | EFDAFSGSLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DFDVHGNLLA | ACGFSSRLTG | LACDRFLKVY | DLRMMRAITP | LQVHVDPAFL | RFIPTYTSRL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIISQSGQCQ | FCEPTGLANP | ADIFHVNPVG | PLLMTFDVSA | SKQALAFGDS | EGCVHLWTDS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEPSFNPYSR | ETEFALPCLV | DSLPPLDWSQ | DLLPLSLIPV | PLTTDALLSD | WPAANSAPAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RRAPPVDAEI | LRTMKKVGFI | GYAPNPRTRL | RNQIPYRLKE | SDHEFDNFSQ | VTESPTGREE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EPLHTVSKKY | RKVTIKYSKL | GLEDFDFKHY | NKTLFAGLEP | HIPNAYCNCM | IQVLYFLEPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RCLIQNHLCQ | KEFCLACELG | FLFHMLDLSR | GDPCQGSNFL | RAFRTIPEAS | ALGLILADSD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EASGKGSLAR | LIQRWNRFIL | TQLHQDMQEL | EVPQAYRGAG | GSFCSSGDSI | IGQLFSCEME |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NCSLCRCGSE | TVRASSTLLF | TLSYPEDKTG | KNYDFAQVLK | RSICLEQNTQ | AWCDNCEKYQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PTIQTRNIRH | LPDILVINCE | VNSSKEADFW | RLQAEVAFKI | AVKKYGGEMK | SKEFALADRK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ELRSPEGFLC | SSIEELKNVW | LPFSIRMKMT | KNKGLDVCNW | ADEHELSSLG | APSQWGPARA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EEELGVYVYD | LMATVVHILD | SRTGGSLVAH | IKVGETYHQR | KEGVTHQQWY | LFNDFLIEPI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DKYEAVQFDM | NWKVPAILYY | VKRNLNSRYN | LNIKNPIEAS | VLLAEASLAR | KQRKTHTTFI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PLMLNEMPQV | GDLVGLDAEF | VTLNEEEAEL | RSDGTKSTIK | PSQMSVARIT | CVRGQGPNEG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IPFIDDYIST | QEQVVDYLTQ | YSGIKPGDLD | AKISSKHLTT | LKSTYLKLRF | LIDIGVKFVG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| HGLQKDFRVI | NLMVPKDQVL | DTVYLFHMPR | KRMISLRFLA | WYFLDLKIQG | ETHDSIEDAR |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| TALQLYRKYL | ELSKNGTEPE | SFHKVLKGLY | EKGRKMDWKV | PEPESQTSPK | NAAVFSVLAL |