AiPD: Autoinhibited Protein Database

Gene name	Nelfa (Whsc2, Whsc2h)
Protein name	Negative elongation factor A
Names	NELF-A, Wolf-Hirschhorn syndrome candidate 2 homolog, mWHSC2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:24116
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

235-406 (Predicted disordered autoinhibitory region) PR

235-406 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BG30-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388755373	2	A>T	No	EVA
rs3388755309	24	W>*	No	EVA
rs3388747428	24	W>R	No	EVA
rs3388751188	28	S>I	No	EVA
rs3388755741	44	C>*	No	EVA
rs3388737989	64	P>T	No	EVA
rs3395396562	69	D>H	No	EVA
rs3388747463	80	Q>R	No	EVA
rs3388749850	114	N>I	No	EVA
rs3388747817	123	E>D	No	EVA
rs3388755701	124	L>H	No	EVA
rs3388751217	129	S>N	No	EVA
rs3388747424	145	N>S	No	EVA
rs3388747435	180	Q>*	No	EVA
rs3388740614	300	Y>F	No	EVA
rs3388752250	310	L>H	No	EVA
rs3388755792	318	T>I	No	EVA
rs3388761020	329	P>T	No	EVA
rs3388751244	336	S>F	No	EVA
rs3388747443	339	P>S	No	EVA
rs3388751219	372	Q>H	No	EVA
rs3388752264	400	P>L	No	EVA
rs3388754968	437	R>G	No	EVA
rs3388744668	452	K>E	No	EVA
rs3388755780	470	E>K	No	EVA
rs3388747446	502	M>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Hepatitis delta antigen (HDAg) domain	89 - 248	IPR037517

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
NELF complex	A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
molecular adaptor activity	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

Name	Definition
negative regulation of transcription elongation by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
positive regulation of histone H3-K4 methylation	Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9H3P2	NELFA	Negative elongation factor A	Homo sapiens (Human)	PR