Q8BFS9
Gene name |
Asnsd1 |
Protein name |
Asparagine synthetase domain-containing protein 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70396 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BFS9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BFS9-F1 | Predicted | AlphaFoldDB |
66 variants for Q8BFS9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs32777019 | 12 | I>V | No | EVA | |
| rs32777023 | 25 | H>Y | No | EVA | |
| rs247171283 | 36 | R>K | No | EVA | |
| rs3388469487 | 40 | K>N | No | EVA | |
| rs579158072 | 43 | V>I | No | EVA | |
| rs3388469668 | 49 | F>L | No | EVA | |
| rs3388469635 | 58 | G>D | No | EVA | |
| rs3388469912 | 60 | L>F | No | EVA | |
| rs3388470116 | 69 | H>Q | No | EVA | |
| rs3388469940 | 80 | F>L | No | EVA | |
| rs32777759 | 86 | E>K | No | EVA | |
| rs231968955 | 94 | V>F | No | EVA | |
| rs231968955 | 94 | V>I | No | EVA | |
| rs262788900 | 96 | F>S | No | EVA | |
| rs32777761 | 106 | S>C | No | EVA | |
| rs3388470450 | 113 | S>F | No | EVA | |
| rs245880651 | 140 | R>Q | No | EVA | |
| rs3388470320 | 147 | F>L | No | EVA | |
| rs3388468967 | 148 | S>I | No | EVA | |
| rs3388469181 | 157 | S>* | No | EVA | |
| rs32777763 | 161 | T>A | No | EVA | |
| rs222127390 | 163 | V>I | No | EVA | |
| rs32778455 | 164 | Y>S | No | EVA | |
| rs3388468968 | 176 | S>A | No | EVA | |
| rs3388470452 | 176 | S>F | No | EVA | |
| rs3388469950 | 185 | S>T | No | EVA | |
| rs239543159 | 200 | R>I | No | EVA | |
| rs239543159 | 200 | R>K | No | EVA | |
| rs32778457 | 206 | D>N | No | EVA | |
| rs32778457 | 206 | D>Y | No | EVA | |
| rs32778459 | 223 | P>S | No | EVA | |
| rs3389959114 | 254 | E>D | No | EVA | |
| rs3389959106 | 255 | I>F | No | EVA | |
| rs3388469472 | 258 | R>* | No | EVA | |
| rs212518942 | 263 | T>I | No | EVA | |
| rs3388470039 | 287 | I>F | No | EVA | |
| rs3388469557 | 317 | S>R | No | EVA | |
| rs236055060 | 318 | S>L | No | EVA | |
| rs3388468981 | 340 | D>Y | No | EVA | |
| rs234584174 | 341 | R>H | No | EVA | |
| rs247057441 | 350 | D>N | No | EVA | |
| rs247057441 | 350 | D>Y | No | EVA | |
| rs3388469883 | 353 | N>K | No | EVA | |
| rs3388470003 | 354 | V>L | No | EVA | |
| rs586762711 | 357 | V>M | No | EVA | |
| rs231543688 | 363 | G>R | No | EVA | |
| rs583141630 | 382 | E>G | No | EVA | |
| rs214948122 | 388 | P>T | No | EVA | |
| rs253858631 | 396 | E>D | No | EVA | |
| rs32779139 | 416 | N>T | No | EVA | |
| rs3388469670 | 419 | R>Q | No | EVA | |
| rs3388469311 | 428 | V>D | No | EVA | |
| rs247555388 | 448 | L>S | No | EVA | |
| rs3388470268 | 458 | C>Y | No | EVA | |
| rs3388469626 | 488 | T>S | No | EVA | |
| rs3388469991 | 491 | G>S | No | EVA | |
| rs3388470281 | 494 | E>D | No | EVA | |
| rs3388468956 | 515 | N>D | No | EVA | |
| rs3388469771 | 536 | V>G | No | EVA | |
| rs3388468897 | 573 | G>E* | No | EVA | |
| rs3388470007 | 576 | E>V | No | EVA | |
| rs3388469970 | 577 | K>E | No | EVA | |
| rs3388470443 | 578 | L>I | No | EVA | |
| rs32777339 | 601 | Q>H | No | EVA | |
| rs3388469544 | 611 | K>I | No | EVA | |
| rs3388470479 | 621 | G>V | No | EVA |
No associated diseases with Q8BFS9
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| asparagine synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| asparagine biosynthetic process | The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. |
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCGICCSVSF | SIEHFSKELK | EDLLHNLRRR | GPNSSRQLLK | SAVNYQCLFS | GHVLHLRGVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TIQPVEDEHG | NVFLWNGEVF | NGVKVEAEDN | DTQVMFNSLS | ACKNESEILL | LFSKVQGPWS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FIYYQASSHH | LWFGRDFFGR | RSLLWQFSNL | GKSFCLSSVG | TQVYGVADQW | QEVPASGIFQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDLNSAAVSR | SVILKLYPWR | YISKEDIAEE | CGNDLTQTPA | GLPEFVSVVI | NEANLYLSKP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVPLNKKLPE | SPLEIQCRNS | SSTSGTRETL | EVFLTDEHTK | KIVQQFIAIL | NVSVKRRILC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAREENLASK | EVLKTCSSKA | NIAILFSGGV | DSMVIAALAD | RHIPLDEPID | LLNVAFVPKQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KTGLPIPNIE | RKQQNHHEIP | SEESSQSPAA | DEGPGEAEVP | DRVTGKAGLK | ELQSVNPSRT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WNFVEINVSL | EELQKLRRAR | ICHLVQPLDT | VLDDSIGCAV | WFASRGIGWL | VTQDAVRSYK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SSAKVILTGI | GADEQLAGYS | RHRARFQSLG | LEGLNEEIAM | ELGRISSRNL | GRDDRVIGDH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GKEARFPFLD | ENVVSFLNSL | PVWEKVDLTL | PRGVGEKLIL | RLAAMELGLP | ASALLPKRAI |
| 610 | 620 | ||||
| QFGSRIAKLE | KSNEKASDKC | GRLQILP |