Q8BFR6

PR
Gene name
Zfand1
Protein name
AN1-type zinc finger protein 1
Names
Zinc finger AN1-type-containing protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66361
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

86-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q8BFR6

Entry ID Method Resolution Chain Position Source
1WFE NMR - A 44-116 PDB
1WYS NMR - A 1-62 PDB
AF-Q8BFR6-F1 Predicted AlphaFoldDB

16 variants for Q8BFR6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388619629 21 L>H No EVA
rs214292475 63 S>P No EVA
rs223811108 71 D>E No EVA
rs3388623679 71 D>G No EVA
rs3388619602 72 V>I No EVA
rs213187982 73 E>D No EVA
rs244824454 104 A>P No EVA
rs3392709384 120 D>E No EVA
rs3388606287 120 D>N No EVA
rs3392698266 125 G>V No EVA
rs256785677 126 A>T No EVA
rs236420908 144 A>V No EVA
rs3388625834 176 E>Q No EVA
rs3388626361 181 M>I No EVA
rs3388623647 187 W>E No EVA
rs3388615669 211 A>V No EVA

No associated diseases with Q8BFR6

2 regional properties for Q8BFR6

Type Name Position InterPro Accession
domain Zinc finger, AN1-type 4 - 52 IPR000058-1
domain Zinc finger, AN1-type 58 - 106 IPR000058-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, Stress granule
  • Colocalizes with TIA1, G3BP1, VCP and 26S proteasome in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment in a VCP-independent manner
  • Not localized in SGs in response to other heat- oxidative- or osmotic-induced stress treatments
  • Colocalizes with VCP in cytoplasmic speckles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.

2 GO annotations of molecular function

Name Definition
proteasome binding Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
cellular response to arsenite ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.
positive regulation of intracellular protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
stress granule disassembly The disaggregation of a stress granule into its constituent protein and RNA parts.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8TCF1 ZFAND1 AN1-type zinc finger protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MAELDIGQHC QVQHCRQRDF LPFVCDGCSG IFCLEHRSKD SHGCSEVNVV KERPKTDEHK
70 80 90 100 110 120
SYSCSFKGCT DVELVAVICP YCEKNFCLRH RHQSDHDCEK LEVAKPRMAA TQKLVRDIVD
130 140 150 160 170 180
AKTGGAASKG RKGAKSSGTA AKVALMKLKM HADGDKSLPQ TERTYFQVYL PKGSKEKSKA
190 200 210 220 230 240
MFFCLRWSIG KVVDFAASLA NLRNENNKLT AKKLRLCHVP SGEALPLDHT LERWITKEEC
250 260
PLYNGGNVIL EYLNDEEQFL KNVDSYLE