Q8BCV9

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Mirafiori lettuce virus (isolate Lettuce/Netherlands/LS301-O) (MiLV) (Mirafiori lettuce big-vein virus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

185-258 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q8BCV9

Entry ID Method Resolution Chain Position Source

No variants for Q8BCV9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8BCV9

No associated diseases with Q8BCV9

1 regional properties for Q8BCV9

Type Name Position InterPro Accession
domain Mononegavirales RNA-directed RNA polymerase catalytic domain 638 - 804 IPR014023

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDDFMKEKKI NYLKTPYLRT LLESYKEDYV SLKSTIEAEK KKEAREIDVN YPHILTDLIE
70 80 90 100 110 120
RDRDEVVSLE KIGTPSVISK INSPYTEISE ENLNMIKGAL YPEKWNRKAH LELLLFREFF
130 140 150 160 170 180
LSRLDKESEI SYDLSQDGSI ELVKRLYNGG YASPESNVVY KFANTLVSHE LSKIEMNMLG
190 200 210 220 230 240
TQEMKFNEDE ISLDSAKKYW VLDVLEHLNK NIMMKASARE NKRDAPDSID FYEGKRIKTN
250 260 270 280 290 300
YFGVGSSISR IEFENSLPPL VIFLSSTICG YYFEGEAKCF IGKAEMMNYS MYLADNLLTL
310 320 330 340 350 360
SLIRTKLSTE EKKFMDYYVS LLDQPLKTRV GMGALYETTC LLMSDQKTLS SSMPILDNLI
370 380 390 400 410 420
ESIEVSTEQT EIIVEVCISV GPETCIKMSS LGKTLILAST NPSKGLSKYT QRTNRDNPVN
430 440 450 460 470 480
INTIRRLRSL FRQRVIISYI EKHGRVPNLI SVPEDLGAQL EMKAAGGNYL GHMISEISRY
490 500 510 520 530 540
DSVRLGKFLD TGKEMNLQSR IIDKACTKDS YDSENNSEKE IQYYISNDMK EVFKDPIAID
550 560 570 580 590 600
RDQYKSKERL VKVVHRKEPL MMPMKKYLNV RLSAKEKEQK TAARFYGIAS FKLKLWISST
610 620 630 640 650 660
MEMIKRAMKL LPGQMMTMTD DERRLIMFKM SEKLLSKNSY SLFLDYSGHN TSQRPENTNF
670 680 690 700 710 720
ILEEIANMYG YYEGTPEFNE LTSLSYVFSN INIIVEDSWS DYVYISQGQL GAIEGWLGSL
730 740 750 760 770 780
WGIQSQLMIE DMFMQLGMND YIGTTYSDDS CGVFTQSSLD VHKLNGIIKN VQRYGEDMGL
790 800 810 820 830 840
IVKLSQTQVT NGRCSMLKEH YYRGKPMDMS IKKMMSISPN GPKLLGDELE SATLIDSGYT
850 860 870 880 890 900
SSCTRASEIG IQTLLRNFRI VKLLSNSTRK LIEDIDNDIL DERYLSSKNN YEISMKIAAK
910 920 930 940 950 960
NLSKNRLSSY IPAPRSRVIE FYQFHVTNEK VLDLYLMIMY SPYTLYGYAL TPMPDVLISG
970 980 990 1000 1010 1020
YSLSNVKRLA YLQGILGKEA LIVLSKLINL SGNALSYIDN PFPFVGGRKD TKLLIKPIIV
1030 1040 1050 1060 1070 1080
KQLPKRVRNP ELLKLLSLQK DKEEINFKTK IVEVFENCFS SRIASKFYEC SIYSYISGVI
1090 1100 1110 1120 1130 1140
SKVDNSTTMK MLLGGRKMMS LINDAWMRNH KLRIRLNDKG IMNYNELLFA RNQKVLKYKN
1150 1160 1170 1180 1190 1200
DEEIKLNFLE IEEIPIMGKV KYSEYRNMMQ PIFKGSTKLT EQGKKNVPPQ KTFFNIAKFD
1210 1220 1230 1240 1250 1260
RELGVDGMFE HKLIFQAYDL VRYVKWLMME QERFSKKMNE KDELNLTKLC NMTLHTFTDA
1270 1280 1290 1300 1310 1320
SYHDLQEHVV CPKGGRYFHR ALTSGFNPKT GDLSSNIYSS SYDITGIDQL LAKTGGADNN
1330 1340 1350 1360 1370 1380
LNIQYLLIYV RICLSLLRPS PNKLRSLTLT NDIYFNIKDV TFSLENLNDP GSSETLYEVA
1390 1400 1410 1420 1430 1440
SRDKIQSRGK LYYNYSTYIE MDEDLENKFI DHVSTTRQEF IEKESAFRSV HSYMLDQMII
1450 1460 1470 1480 1490 1500
SPELISDLIL EGLIGKKMIS KGRERFFDQF YKYYKSLNVI GAETPARSVI RGLLYEELFK
1510 1520 1530 1540 1550 1560
VNPKSKKGEL WSTEIIKHGY SSGFKDSLMK LFILSTSLSY RMLDKQNGKM KLIVNLNRTV
1570 1580 1590 1600 1610 1620
QNSKSNFERI RKGECQFYIK DKRITEMILN SFPTLGYTYS DVHQAATDVC CEISDMEFEQ
1630 1640 1650 1660 1670 1680
VRLGSYYLKL HKAETNKIEG MVYGYVNFSE LEINYQDLLD NLGLESALKG FETACSLMVS
1690 1700 1710 1720 1730 1740
PEQLSSPTLS AVYPSAKGLL DSLIGNGFIK NSDTIIELCG GRGDFHLAMM EKEIKHTTLS
1750 1760 1770 1780 1790 1800
REDGYNLAMR IPGMTSKKVS FNCFRQSDYI PYFDHSIILL DISHITEKKD CLSGILGDCI
1810 1820 1830 1840 1850 1860
TSKKKVILRL NGLNKFLNYE ILQELKMYEM KAYLPVLESP GYVYLTIDAS KKLEEEKQLD
1870 1880 1890 1900 1910 1920
RKIFTDQLGY SRSILTCSLI NSISIVNLQG VISVPPKRVQ DQTMEVISDE VLTEMILEED
1930 1940 1950 1960 1970 1980
PEYVHVNPEI KTQVKTADDF KDNLYVYISE KLSIKYKNKL KFLEERLITK GKIEKSENKP
1990 2000 2010 2020 2030 2040
KNLIELARKI RRKESDTIEV DYRMLINSKV NIISGVTGMD HNELVEVLND AMSVKFNKRM
2050 2060 2070 2080 2090 2100
SFECWKLILN LSANEKLIDS DLIVETINIQ KFRKDVDRTI NSSFEIASKA VISFKTGRIV
2110 2120 2130 2140 2150 2160
EGLLAVARLD NVRRKSILNH KDKTTRNNIL HYKLYMNRIM IISQSMYVEP QFPGISDSKF
2170 2180 2190 2200 2210 2220
GKIWRSLGSI ESDIDIERAN AALDSIESLN KFFKEMNDEY FSFLNNFDLS VDNMTERIKE
2230 2240 2250 2260 2270
ECQPIDALVD TLTTFGLEVT EEDIARNKEL DTWEKVQEYC GEEELFDAWA QEDIGDWGDE