Q8AXV1
Gene name |
SH3GL2 |
Protein name |
Endophilin-A1 |
Names |
Endophilin-1, SH3 domain-containing GRB2-like protein 1, SH3p4 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:395203 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8AXV1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8AXV1-F1 | Predicted | AlphaFoldDB |
No variants for Q8AXV1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8AXV1 | |||||
No associated diseases with Q8AXV1
1 regional properties for Q8AXV1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | MATH/TRAF domain | 7 - 132 | IPR002083 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| synaptic vesicle uncoating | The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KJA1 | SH3GL1 | Endophilin-A2 | Bos taurus (Bovine) | PR |
| Q8AXU9 | SH3GL3 | Endophilin-A3 | Gallus gallus (Chicken) | PR |
| Q99961 | SH3GL1 | Endophilin-A2 | Homo sapiens (Human) | PR |
| Q99963 | SH3GL3 | Endophilin-A3 | Homo sapiens (Human) | PR |
| Q99962 | SH3GL2 | Endophilin-A1 | Homo sapiens (Human) | PR |
| Q9Y371 | SH3GLB1 | Endophilin-B1 | Homo sapiens (Human) | PR |
| Q62421 | Sh3gl3 | Endophilin-A3 | Mus musculus (Mouse) | PR |
| Q62419 | Sh3gl1 | Endophilin-A2 | Mus musculus (Mouse) | PR |
| Q62420 | Sh3gl2 | Endophilin-A1 | Mus musculus (Mouse) | PR |
| Q9JK48 | Sh3glb1 | Endophilin-B1 | Mus musculus (Mouse) | PR |
| O35180 | Sh3gl3 | Endophilin-A3 | Rattus norvegicus (Rat) | PR |
| O35179 | Sh3gl2 | Endophilin-A1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVAGLKKQF | HKATQKVSEK | VGGAEGTKLD | DDFKEMERKV | DVTSRAVMEI | MAKTIEYLQP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NPASRAKLSM | INTMSKIRGQ | EKGPGYPQAE | ALLADAMLKF | GRELGEECNF | GPALADVGEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MKELSEVKDS | LDMEVKQNFI | DPLQNLHDKD | LREIQHHLKK | MEGRRLDFDY | KKKRQGKLPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EELRQALEKF | DESKEIAESS | MFNLLEMDIE | QVSQLSALVQ | AQLEYHKQAT | QILQRVTSKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDRIKEASSQ | PKREYQPKPR | MSLDFTSGGD | NTQHNGGISH | ATTPKPAGAH | MDQPCCRALY |
| 310 | 320 | 330 | 340 | 350 | |
| DFEPENEGEL | GFKEGDIITL | TNQIDENWYE | GMLHGQSGFF | PINYVDILVP | LPN |