Q8AXC6

PR
Gene name
kit
Protein name
Mast/stem cell growth factor receptor Kit
Names
SCFR, Tyrosine-protein kinase kit
Species
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

905-984 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8AXC6

Entry ID Method Resolution Chain Position Source
AF-Q8AXC6-F1 Predicted AlphaFoldDB

No variants for Q8AXC6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8AXC6

No associated diseases with Q8AXC6

16 regional properties for Q8AXC6

Type Name Position InterPro Accession
domain Protein kinase domain 579 - 926 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 579 - 912 IPR001245
conserved_site Tyrosine-protein kinase, receptor class III, conserved site 638 - 651 IPR001824
domain Immunoglobulin subtype 2 35 - 94 IPR003598-1
domain Immunoglobulin subtype 2 217 - 291 IPR003598-2
domain Immunoglobulin subtype 29 - 103 IPR003599-1
domain Immunoglobulin subtype 114 - 197 IPR003599-2
domain Immunoglobulin subtype 211 - 302 IPR003599-3
domain Immunoglobulin subtype 314 - 403 IPR003599-4
domain Immunoglobulin-like domain 23 - 97 IPR007110-1
domain Immunoglobulin-like domain 203 - 300 IPR007110-2
domain Immunoglobulin-like domain 398 - 498 IPR007110-3
active_site Tyrosine-protein kinase, active site 777 - 789 IPR008266
domain Immunoglobulin I-set 208 - 301 IPR013098
binding_site Protein kinase, ATP binding site 585 - 613 IPR017441
domain Tyrosine-protein kinase, catalytic domain 579 - 913 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cytokine binding Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
metal ion binding Binding to a metal ion.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

2 GO annotations of biological process

Name Definition
Fc receptor signaling pathway The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Kit signaling pathway The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEYHWILLCV SLCFTFHPGD TKPTITPAGT YVVVSLNAPL ELQCQGEKAM QWQREERPKV
70 80 90 100 110 120
RGETKVDGKS TLYIPKAHPA HMGRYICLEE TSQERASIYI YVKDPDNPFR KSMVSNILSR
130 140 150 160 170 180
EGDSASIPCL ATDPSLENLQ LKTCSSKALA SGLHFSPSLE QGIIIHNTQK SYEGCYVCTG
190 200 210 220 230 240
RLKETNVRSH DYHLTVRPVP VAPPVIMMQA PKRVILIRDE SLYLTCNTTN VNGNIKLKWV
250 260 270 280 290 300
APLGSQPAKV DGSSRILTEN FTQARSATLH IAAVRIQDTG RYQCEAENEK GVSTQSVWLD
310 320 330 340 350 360
VFEKGFMYSN PVNNGTIQVR AGESLLLSVS IEAYPMPRSA SWSFMGRGLH NTSDHVITTR
370 380 390 400 410 420
SHEYTYSSEL KLVRLKMSEG GVYTFQASNG DASVNHTFTI FVISKPEIVS HEGPVDGQVR
430 440 450 460 470 480
CVAEGFPAPQ ITWYYCEQPY ARCSQQVNAT QEEQNVITVT LFSPLFGKTE VESRVNISRG
490 500 510 520 530 540
RFSTLECVAT VEGEQAFTLF SISERTISHD LFSPLLIGSV SAACILCLIL IVLFYKYMQK
550 560 570 580 590 600
PKYQIQWKVI EGIHGNNYVY IDPTQLPYDH QWEFPRKNLR FGKTLGSGAF GKVVEATAYG
610 620 630 640 650 660
LANEDSMMTV AVKMLKSSAH STEKEALMSE LKVLIYLGNH INIVNLLGAC TVGGPTLVIT
670 680 690 700 710 720
EYCCFGDLLN FLRRKRESFI CFKLEEDCHY RNIMLQREMA GDSLNGYMTM RPSAAGKPSS
730 740 750 760 770 780
SSSSEKRRSL REGSPYVEED SESEMFDEDS LSLDTEDLLS FSYQVAKGME FLTSKNCIHR
790 800 810 820 830 840
DLAARNILLT QGRVAKICDF GLARDINTDS NYVVKGNARL PVKWMSPESI FECVYTFESD
850 860 870 880 890 900
VWSYGILLWE IFSLGNSPYP GMPVDAKFYK LIKEGYRMDA PEFAPSEMYQ IMRSCWDADP
910 920 930 940 950 960
LNRPPFRKVV ERIEQQLSDT TKHIYLNFSS RVPVMPRGRE ESSTHSMASQ PFNSAGNNSP
970 980
PSRPLLLHHE VFLEGTEPFR VQRV