Q8AXB4

PR
Gene name
pak3
Protein name
Serine/threonine-protein kinase PAK 3
Names
p21-activated kinase 3, PAK-3
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:378493
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

113-295 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

424-447 (Activation loop from InterPro)

Target domain

268-564 (Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8AXB4

Entry ID Method Resolution Chain Position Source
AF-Q8AXB4-F1 Predicted AlphaFoldDB

No variants for Q8AXB4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8AXB4

No associated diseases with Q8AXB4

6 regional properties for Q8AXB4

Type Name Position InterPro Accession
domain CRIB domain 69 - 141 IPR000095
domain Protein kinase domain 288 - 539 IPR000719
active_site Serine/threonine-protein kinase, active site 403 - 415 IPR008271
binding_site Protein kinase, ATP binding site 294 - 317 IPR017441
domain p21 activated kinase binding domain 68 - 128 IPR033923
domain p21-activated kinase 3, catalytic domain 268 - 564 IPR035063

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

9 GO annotations of biological process

Name Definition
anterior neural plate formation The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cement gland development The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed.
negative regulation of neuroblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.
neural plate formation The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
positive regulation of neuron differentiation Any process that activates or increases the frequency, rate or extent of neuron differentiation.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDSVDIEEK PPAPPLRMNS NNRDSSALNH CSKPLPMAPE EKNKKARLRS IFPGGGDKTN
70 80 90 100 110 120
KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLCGSQM GTGKLPEGIP EQWARLLQTS
130 140 150 160 170 180
NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHS LNAKTASEPP
190 200 210 220 230 240
LAPPVSEEED EEEEEEEDDN EPPPVIAPRP EHTKSIYTRS VIEPVALTAP AKEASTSPVT
250 260 270 280 290 300
PQPENSNSST STLYRNTDRQ RKKSKMTDEE ILEKLRSIVS VGDPKKKYTR FEKIGQGASG
310 320 330 340 350 360
TVYTAIDIAT GQEVAIKQMN LQQQPKKELI INEILVMREN KNPNIVNYLD SYLVGDELWV
370 380 390 400 410 420
VMEYLAGGSL TDVVTETCMD EGQIAAVCRE CLQALDFLHS NQVIHRDIKS DNILLGMDGS
430 440 450 460 470 480
VKLTDFGFCA QITPEQSKRS TMVGTPYWMA PEVVTRKAYG PKVDIWSLGI MAIEMVEGEP
490 500 510 520 530 540
PYLNENPLRA LYLIATNGTP ELQNPERLSA IFRDFLNRCL EMDVDRRGSA KELLQHPFLK
550 560
IAKPLSSLTP LIIAAKEAIK NSSR