Q8AVM5

PR
Gene name
atp6v0a1
Protein name
V-type proton ATPase 116 kDa subunit a1
Names
V-ATPase 116 kDa subunit a1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

112-195 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8AVM5

Entry ID Method Resolution Chain Position Source
AF-Q8AVM5-F1 Predicted AlphaFoldDB

No variants for Q8AVM5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8AVM5

No associated diseases with Q8AVM5

No regional properties for Q8AVM5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8AVM5

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.
vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

1 GO annotations of molecular function

Name Definition
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
70 80 90 100 110 120
MDRKLRFVEK EVKKANISIL DTGENPEVPF PRDIIDLEAN FEKIEIELKE INTNQEALKR
130 140 150 160 170 180
NFLELTELKF ILRKTQQFFD EMADPDLLEE SSTLLEPSEM GRGAPLRLGF VAGVINRERI
190 200 210 220 230 240
PTFERMLWRV CRGNVFLRQA QIENPLEDPV TGDSVHKSVF IIFFQGDQLK NRVKKICEGF
250 260 270 280 290 300
RASLYPCPET PQERKEMATG VNTRIEDLQM VLNQTEDHRQ RVLQAAAKSL RVWFIKVRKM
310 320 330 340 350 360
KAIYHTLNLC NIDVTQKCLI AEVWCPVADL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT
370 380 390 400 410 420
PPTYNKTNKF TYGFQNLVDA YGIGSYREIN PAPYTIITFP FLFAVMFGDF GHGILMTLFA
430 440 450 460 470 480
VWMVVRESRI LSQKIDNELF SMMFSGRYII LLMGLFSTYT GLIYNDCFSK ALNLFGSSWS
490 500 510 520 530 540
VRPMFTDTWS EDLLKHTSVL QLNPNVTGVF NGPYPFGIDP IWSLATNKLT FLNSFKMKMS
550 560 570 580 590 600
VILGIIHMIF GVALSVLNHI YFKKPLNIYL SFIPEMIFMT TLFGYLVILI IYKWCAYDVS
610 620 630 640 650 660
TSMVAPSLLI HFINMFLFSY QDTSLPMLYK GQMGLQCFLV VCAIICVPWM LVLKPLILRR
670 680 690 700 710 720
QYLRRKHLGT HNFGGIRVGN GPTEEDAEII QHDQLSMHSD EEEEFDFGDT VVHQAIHTIE
730 740 750 760 770 780
YCLGCISNTA SYLRLWALSL AHAQLSEVLW TMVMHIGLNI RSLGGGIALV FIFSAFATLT
790 800 810 820 830
IAILLIMEGL SAFLHALRLH WVEFRNKFYM GTGFKFLPFS FETIWEGKFD D