Q8AVJ9

PR
Gene name
fzd7-b (fz7-b)
Protein name
Frizzled-7-B
Names
Fz-7-B, Xfz7-B
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8AVJ9

Entry ID Method Resolution Chain Position Source
AF-Q8AVJ9-F1 Predicted AlphaFoldDB

No variants for Q8AVJ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8AVJ9

No associated diseases with Q8AVJ9

4 regional properties for Q8AVJ9

Type Name Position InterPro Accession
domain Frizzled/Smoothened, transmembrane domain 217 - 541 IPR000539
domain GPCR, family 2-like, transmembrane domain 225 - 530 IPR017981
domain Frizzled domain 31 - 152 IPR020067
domain Frizzled-7, cysteine-rich Wnt-binding domain 32 - 156 IPR042742

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Endosome membrane ; Multi-pass membrane protein
  • Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2)
  • Localized in recycling endosomes in other conditions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endosome membrane The lipid bilayer surrounding an endosome.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
syndecan binding Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
Wnt receptor activity Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Wnt-protein binding Binding to a Wnt-protein, a secreted growth factor involved in signaling.

6 GO annotations of biological process

Name Definition
convergent extension involved in gastrulation The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
dorsal/ventral axis specification The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
mesoderm formation The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
tissue morphogenesis The process in which the anatomical structures of a tissue are generated and organized.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLAPVSLLFC LFLQLCPSAQ QYHGEKGISV PDHGFCQPIS IPLCTDIAYN QTIMPNLLGH
70 80 90 100 110 120
TNQEDAGLEV HQFYPLVKVQ CSPELRFFLC SMYAPVCTVL EQAIPPCRSL CERARQGCEA
130 140 150 160 170 180
LMNKFGFQWP ERLRCENFPV HGAGEICVGQ NTSDNSPSGP TARPTLNLPD SITFQPHPHR
190 200 210 220 230 240
DFTCPRQLKV PPYLGYRFLG EKDCGAPCEP GKANGLMYFK EEEVRFARLW VGIWAILCGI
250 260 270 280 290 300
STLFTVLTYL VDMRRFSYPE RPIIFLSGCY FMVAVAYTAG FLLEERAVCV ERFSEDSYRT
310 320 330 340 350 360
VAQGTKKEGC TILFMILYFF GMASSIWWVI LALTWFLSAG MKWGHEAIEA NSQYFHLAAW
370 380 390 400 410 420
AVPAVKTITI LAMGQVDGDV LSGVCYVGIN SVDSLRGFVL APLFVYLFLG TSFLLAGFVS
430 440 450 460 470 480
LFRIRTIMKH DGTKTEKLEK LMVRIGVFSV MYTVPATIVL ACYFYEQAFR DTWEKTWLVH
490 500 510 520 530 540
TCKGYAVPCP NYNFAPMSPD FTVFMIKYLM TMIVGITSSF WIWSGKTLQS WRRFYHRLGN
GSKGETAV