Q8A5W4

PR
Gene name
lysS
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
KEGG Pathway
bth:BT_2122
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

395-547 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8A5W4

Entry ID Method Resolution Chain Position Source
AF-Q8A5W4-F1 Predicted AlphaFoldDB

No variants for Q8A5W4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8A5W4

No associated diseases with Q8A5W4

6 regional properties for Q8A5W4

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 162 - 499 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 55 - 138 IPR004365
domain Aminoacyl-tRNA synthetase, class II 189 - 501 IPR006195
domain Lysyl-tRNA synthetase, class II, C-terminal 176 - 501 IPR018149
domain Domain of unknown function DUF4332 515 - 574 IPR025567
domain Lysine-tRNA ligase, class II, N-terminal 54 - 173 IPR044136

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNILELSEQE IIRRNSLNEL RAMGIDPYPA AEYVTNAFST DIKAEFKDED EPRQVSVAGR
70 80 90 100 110 120
IMSRRVMGKA SFIELQDSKG RIQVYITRDD ICPGEDKELY NSVFKRLLDL GDFVGIEGFV
130 140 150 160 170 180
FRTQMGEISI HAKKLTVLAK SIKPLPIVKY KDGVAYDSFE DPELRYRQRY VDLVVNEGIK
190 200 210 220 230 240
ETFEKRATVV RTLRNALDEA GYTEVETPIL QSIAGGASAR PFITHHNSLD IDLYLRIATE
250 260 270 280 290 300
LYLKRLIVGG FEGVYEIGKN FRNEGMDRTH NPEFTCMELY VQYKDYNWMM SFTEKLLERI
310 320 330 340 350 360
CIAVNGSTET VVDGKTISFK APYRRLPILD AIKEKTGYDL NGKSEEEIRQ ICKELKMEEI
370 380 390 400 410 420
DDTMGKGKLI DEIFGEFCEG SYIQPTFITD YPVEMSPLTK MHRSKPGLTE RFELMVNGKE
430 440 450 460 470 480
LANAYSELND PLDQEERFKE QMRLADKGDD EAMIIDQDFL RALQYGMPPT SGIGIGIDRL
490 500 510 520 530 540
VMLMTGQTTI QEVLFFPQMR PEKVIKKDPA AKYMELGIAE DWVPVIQKAG YNTVADMQDV
550 560 570
NPQKLHQDIC GINKKYKLEL TNPSVNDVTE WINKLK