Q8A005

PR
Gene name
menG
Protein name
Demethylmenaquinone methyltransferase
Names
Species
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)
KEGG Pathway
bth:BT_4216
EC number
2.1.1.163: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8A005

Entry ID Method Resolution Chain Position Source
AF-Q8A005-F1 Predicted AlphaFoldDB

No variants for Q8A005

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8A005

No associated diseases with Q8A005

2 regional properties for Q8A005

Type Name Position InterPro Accession
domain Sodium:galactoside symporter 8 - 450 IPR001927
conserved_site Sodium:galactoside symporter, conserved site 59 - 84 IPR018043

Functions

Description
EC Number 2.1.1.163 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
demethylmenaquinone methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine.
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol.
S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+.
S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine.

2 GO annotations of biological process

Name Definition
menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYPQQHIKP YNEDGKKTEQ VERMFDNIAH AYDKLNHTLS LGIDRSWRRK AIAWLRPFRP
70 80 90 100 110 120
QHIMDVATGT GDFAILACRE LNPDELIGTD ISEGMMNVGR EKVKKEGLSD KISFAREDCT
130 140 150 160 170 180
SLSFADNRFD AITVAFGIRN FEDLDKGLSE MCRVLKPGGH LVILELTTPD RFPMKQLFAI
190 200 210 220 230 240
YSKVVIPLLG KLLSKDNSAY HYLPDTIKVF PQGEVMKGVI SKTGFGEVHF RRLTFGICTL
YTATK