Q89MN4

PR
Gene name
kynA
Protein name
Tryptophan 2,3-dioxygenase
Names
TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase
Species
Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
KEGG Pathway
bja:blr4158
EC number
1.13.11.11: With incorporation of two atoms of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q89MN4

Entry ID Method Resolution Chain Position Source
AF-Q89MN4-F1 Predicted AlphaFoldDB

No variants for Q89MN4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q89MN4

No associated diseases with Q89MN4

2 regional properties for Q89MN4

Type Name Position InterPro Accession
active_site Glycoside hydrolase family 1, active site 371 - 379 IPR018120
conserved_site Glycosyl hydrolases family 1, N-terminal conserved site 9 - 23 IPR033132

Functions

Description
EC Number 1.13.11.11 With incorporation of two atoms of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.
tryptophan 2,3-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.

2 GO annotations of biological process

Name Definition
tryptophan catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.
tryptophan catabolic process to kynurenine The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSSDYDPAS EGAETDFSRR MSYGDYLALD AILGAQHPLS EAHDEMLFII QHQTTELWMR
70 80 90 100 110 120
LAIHELSAAR RAIARDEVQP AMKMLARMSR IFEQLNNAWD VLRTMTPSEY TRFRSQLGQS
130 140 150 160 170 180
SGFQSRQYRL IEYLLGNRNH AMLKPHAHDA EVTKLLEAEL ATPSLYDEVL RLADRNGLTM
190 200 210 220 230 240
PAAVLSRDVR ETHSFNEGVL QAWRVVYEAP ETHWMLYELA EKLVDFEDYF RRWRFNHVTT
250 260 270
VERVIGFKRG TGGTGGVSYL KRMLEVELFP ELWRVRTIL