Q89I89

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
KEGG Pathway
bja:bll5750
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

391-464 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q89I89

Entry ID Method Resolution Chain Position Source
AF-Q89I89-F1 Predicted AlphaFoldDB

No variants for Q89I89

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q89I89

No associated diseases with Q89I89

4 regional properties for Q89I89

Type Name Position InterPro Accession
domain DHHA1 domain 746 - 888 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 654 - 708 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 6 - 556 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 2 - 721 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGVNEIRST FLNFFAENGH EIVPSSPLVP RNDPTLMFTN AGMVQFKNVF TGVEKRPYQR
70 80 90 100 110 120
ATTSQKCVRA GGKHNDLDNV GYTARHLTFF EMLGNFSFGD YFKERAIELA WKLITKDFGL
130 140 150 160 170 180
NKDKLLVTVY HTDDEAHGLW KKIAGFSDDR IIRIPTSDNF WAMGDTGPCG PCSEIFIDRG
190 200 210 220 230 240
DHIWGGPPGS PEEDGDRFLE FWNLVFMQYE QVTKEERVDL PRPSIDTGMG LERMACIMQG
250 260 270 280 290 300
VDSVFETDLF RHLIDATASA LGSGPNEQTV ASFRVIADHL RSSAFLVSDG VLPSNEGRGY
310 320 330 340 350 360
VLRRIMRRAM RHAQLLGAKE PLMHRLVWAL VREMGQAYPE LMRAEKLIEE TLRLEETRFR
370 380 390 400 410 420
KTLTRGLAIL DEKSASLKKG DMFDGDVAFT LYDTYGFPLD LTQDALKSRG IGVDQSAFTD
430 440 450 460 470 480
AMERQKAKAR ESWKGSGEAA SEAIWFPLRE KLGATEFLGY ETESAEGVVS ALVKDGQEAA
490 500 510 520 530 540
SLKAGETGAL VLNQTPFYAE SGGQVGDTGV LLGEGGVKFR VTDTQKKLGD LFVHVGTVES
550 560 570 580 590 600
GELKLGTALQ LEVDHSRRSS IRAHHSATHL IHEALRQVLG DHIAQRGSMV APDRLRFDFV
610 620 630 640 650 660
HPKPITAEEL ARVEDIANDV VLENDEVTTR VMGVDEAREA GARALFGEKY GDEVRVVSMG
670 680 690 700 710 720
RTARERGANA LGWSVELCGG THVRRTGDIG LITLTGESAV ASGVRRIEAL TGNYARKHAN
730 740 750 760 770 780
DTMALAKTAA NELRTSIDDV PARITALMEE RKKLERELSD ARKKLAMGGG AAASNGAASG
790 800 810 820 830 840
VREVGDVKLM ARAVEGIEMK DLKSLADDGK KQIGSGVVAI VGVTGDGKAG IVVGVTADLT
850 860 870 880 890
ARFNAVNLVR VASEALGGKG GGGRPDMAQA GGPDGAKAPE ALAAIEKAMA GA