Q89AN8

PR
Gene name
dnaE (bbp_220)
Protein name
DNA polymerase III subunit alpha
Names
Species
Buchnera aphidicola subsp Baizongia pistaciae (strain Bp)
KEGG Pathway
bab:bbp_220
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

894-965 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q89AN8

Entry ID Method Resolution Chain Position Source
AF-Q89AN8-F1 Predicted AlphaFoldDB

No variants for Q89AN8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q89AN8

No associated diseases with Q89AN8

5 regional properties for Q89AN8

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 7 - 74 IPR003141
domain PHP domain 8 - 176 IPR004013
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 296 - 562 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 813 - 900 IPR029460
domain DNA polymerase III alpha subunit finger domain 565 - 739 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFNFKFVHLR VHSDFSMIDG LVKPNILAQH AKKLNMPAIA ITDSSNLHGM IKFYRATFSQ
70 80 90 100 110 120
GIKPIIGVDF KVFPDDKYVS SNMFTKITLL AVNNSGYRNL LLLLSRAYKI GYNNKVGVFI
130 140 150 160 170 180
TKEWLVEHRK GIILLSGGCY GDIGVNLLNN NKSLVLNCLS FYNRFFENFY YLEIMRIGRS
190 200 210 220 230 240
NEEQYISRIK DISAREGIPV VATNEVCFLN KQDFEVHKIR VFINLGCTIK SNSAHYNYTP
250 260 270 280 290 300
QQFMRTSNEM EELFLDFPDA ISNTIEISKR CNVILKFNKY FLPKFQTGNM NTTDFLVMKA
310 320 330 340 350 360
KKGMQKRLIQ LFPNKQDRIN NVNRYYTRLL SELNVINKMG FPGYFLIVME FINWAKKNDI
370 380 390 400 410 420
PVGPGRGSGA GSLVSYVLNI TELDPLSFDL LFERFLNPER VFMPDLDVDF CMDKRDKVIE
430 440 450 460 470 480
HVSKIYGEES VSQIISFGTL TAKSVIRDVG RVFGFPYGFL NRLSKLIPLD LGMTLEKAIS
490 500 510 520 530 540
QKVELLELYK FDKDVRELIN IAKRLEGITR NVSKHAGGVV ISPKKITDFV PLYYDENGNN
550 560 570 580 590 600
PVTQFDKNDI GYTGLVKFDF LGLKTLTVIH GTVKMINTKF SNNQKKLINI NTISLKDKNC
610 620 630 640 650 660
FKFLQTAQTI AVFQLESNGM KDLIRRLKPD SFEDLVALVA LFRPGPLQSG MVDNFINRKH
670 680 690 700 710 720
GKEKILYPNK ECQHALLKPI LKSTYGIILY QEQVMKIVQV FANYTLGHAD LLRRTMEKKD
730 740 750 760 770 780
QVEMNKHREM FKNGAKENNI NTKLSTKIFN LLEQFAGYAF NKSHSVSYAL VSYQTLWLKL
790 800 810 820 830 840
YYPEEFMASA MNADIDNIKK IVVLINECKV MKLKIIPPNV NQSDYYFKVD DDKNIIYGLG
850 860 870 880 890 900
AIKGIGKSVI LDIVNARKNR KRFSELFDLC VSVNSKRITH KVIEKLIMSG GCDCFGLNRS
910 920 930 940 950 960
ILMHSCEYII KSANQYLKSI ILKKRDLFGL LLDDFNVIKK KYYSIKKLYS MKQILDWEKD
970 980 990 1000 1010 1020
SLGLYLTGHP VDEHVHLQMR YNNVIRLKDL FNNKITTEQI SILGMISFLK FKVTKTKKNM
1030 1040 1050 1060 1070
VFMILEDSFV QIEVIIFDNI LRRYRHLLEK EVIIIVTGRI QKSMFSKKYI VLAEKLI