Q89868

PR
Gene name
nef
Protein name
Protein Nef
Names
3'ORF, Negative factor, F-protein
Species
Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q89868

Entry ID Method Resolution Chain Position Source

No variants for Q89868

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q89868

No associated diseases with Q89868

No regional properties for Q89868

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q89868

Functions

Description
EC Number
Subcellular Localization
  • Host cell membrane ; Lipid-anchor ; Cytoplasmic side
  • Associates with the inner plasma membrane through its N-terminal domain
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell plasma membrane The plasma membrane surrounding a host cell.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.

1 GO annotations of biological process

Name Definition
mitigation of host antiviral defense response A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSAGSKKQS KQQPGLRERL LRARRGPRGE SSGERQERSL QYPGGSDKGL NSPSCDGQKT
70 80 90 100 110 120
LGAEGGGKQD SDEDDEDNEV GVRVRPGVPL RPMTFKLAVD MSHFLKEKGE LEGIFYSERR
130 140 150 160 170 180
HKILDTYLEN EEGIVSGWQN YTHGPGVRYP KFFGWLWKLV PINMIAEPED EETHCLVHPA
190 200 210 220 230
QTSAWDDPHE ETLVWQFDSL LAYDYVAFSR FPEEFGYQSG MPEKEWKAKL RARGIPTE