Q895K2

PR
Gene name
polC
Protein name
DNA polymerase III PolC-type
Names
PolIII
Species
Clostridium tetani (strain Massachusetts / E88)
KEGG Pathway
ctc:CTC_01271
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

157-229 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q895K2

Entry ID Method Resolution Chain Position Source
AF-Q895K2-F1 Predicted AlphaFoldDB

No variants for Q895K2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q895K2

No associated diseases with Q895K2

9 regional properties for Q895K2

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 339 - 406 IPR003141
domain PHP domain 340 - 698 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 420 - 639 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 840 - 1021 IPR011708-1
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 1039 - 1108 IPR011708-2
domain Exonuclease, RNase T/DNA polymerase III 424 - 590 IPR013520
domain DNA polymerase III PolC-like, N-terminal domain II 92 - 205 IPR024754
domain DNA polymerase III PolC-type, N-terminal domain I 4 - 78 IPR028112
domain DNA polymerase III alpha subunit finger domain 1112 - 1267 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELAKILEDN TFSQDSLEGI RVHRIQYFKK SNKLKVIVKS KKEVNNNQIT EIKKVFFKKF
70 80 90 100 110 120
QYFKEIEVLS YRDVSGINLK DICEKYWIDI VNSILTYIPF CKECLISSKR KVIDENTLKL
130 140 150 160 170 180
QYGNDFLYNI LKEKNFEKIL SSTIKDVFGV ECKVKFILDK SNGKCNYLDF KEEQEALIIK
190 200 210 220 230 240
NIIKESRIEK TIPKKDNNYN KREENKNSSI IVGKNINEDP VDISNIDETS GIISICGDVF
250 260 270 280 290 300
KTKIIETKTG RKIVTFYITD YTSSITVKLF PKPKDTERVI EEIKEGLYCK IRGEVVNDSY
310 320 330 340 350 360
AREIVIMARD IVKLNKIEKM DIAEEKRVEL HLHTKMSAMD GMNSAESLIK RAAKWGHKAV
370 380 390 400 410 420
AITDHGVVQA YPEAMEAAKK YNIKIIYGVE GYLVDDGIPI AINAGHRTLE DSYVVFDIET
430 440 450 460 470 480
TGFSNKNDKI IEIGAVKIKE GKVVDKYSTF VNPERIIPEK IIELTGIHDY MVKDAPKIEE
490 500 510 520 530 540
VLPKFIDFIE DSILVAHNAN FDVSFIKKNC KDFGIHFNNP ILDTIPLCKF LYPELKRYKL
550 560 570 580 590 600
NVVAKHLGIP LLNHHRAVED AKTTGDILLK AFEDLKDKEI MNLNMLNEEY FKNQDIKKSP
610 620 630 640 650 660
TYHVIILVKN KIGLKNLYKL ISESHLNHFY KKPRMPKSLI NKYREGLMIG SACEAGQVYK
670 680 690 700 710 720
EVLMDKSKEE LKEVISFYDY LEIQPIKNNY FMIRNGIVKD EEELRDINKK IYNLAEENNM
730 740 750 760 770 780
PVVATCDVHF LDKKDEVFRK ILMAGQGFSD AENQPPLYLR TTDEMLKEFE YLGKEKAYKA
790 800 810 820 830 840
VVTNTVKIAD SIDNIKPIPD ETFPPKIEGS EEEVRKMTIE KAHSIYGEVL PEIVEKRLEK
850 860 870 880 890 900
ELNSIINNGY AVLYLIAHKL VDKSVQDGYL VGSRGSVGSS LVATMTDITE VNGLPPHYVC
910 920 930 940 950 960
PGCKYNEFIT DGSVSSGADL PDKNCPNCGV LLSKDGHDIP FETFLGFEGD KEPDIDLNFS
970 980 990 1000 1010 1020
GEYQAVVHKY TEVLFGEGKV FKAGTIGTIA EKTAYGFVKK YISEKDLNVR QAEIERLTLG
1030 1040 1050 1060 1070 1080
CSGVKRTTGQ HPGGIMVVPQ DNEIFNFTPI QRPADDNDTD IITTHFDYHS ISGRLLKLDI
1090 1100 1110 1120 1130 1140
LGHDDPTVLR MLQDLTGVDP KKIPLADPKV MSLFTSPKAL GVNAEELKCE VGTYGLPEFG
1150 1160 1170 1180 1190 1200
TKFVRQMLVD TQPNSFSDLV RISGLSHGTD VWLNNAQYYI KEGYTTLKDC IATRDDIMTY
1210 1220 1230 1240 1250 1260
LIQKDLPPKI AFTIMEKVRK GKGLTEEHEA IMREHDVPGW YIESCKKIKY MFPKGHAVAY
1270 1280 1290 1300 1310 1320
VMMAVRIAYF KVYYPTAYYA TYFSVRASDF DAETVFKGEE AILNKIDEIN SLGNNVTQKD
1330 1340 1350 1360 1370 1380
KGLLTVLEIC HEMNLRGIKF LKADLYKSNA SKFLIEEEGI RIPLSAIQGV GENAAKNIVE
1390 1400 1410 1420
AREEGEFISK EDLNKRGKAT KTVIENLENH GCLRGLPESN QLSLFNL