Q88MW1

PR
Gene name
purT
Protein name
Formate-dependent phosphoribosylglycinamide formyltransferase
Names
5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2
Species
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
KEGG Pathway
ppu:PP_1457
EC number
6.3.1.21: Acid--ammonia (or amine) ligases (amide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

196-272 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q88MW1

Entry ID Method Resolution Chain Position Source
AF-Q88MW1-F1 Predicted AlphaFoldDB

No variants for Q88MW1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q88MW1

No associated diseases with Q88MW1

3 regional properties for Q88MW1

Type Name Position InterPro Accession
domain NAD-dependent epimerase/dehydratase 21 - 81 IPR001509
domain ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type 123 - 294 IPR003135
domain ATP-grasp fold 119 - 308 IPR011761

Functions

Description
EC Number 6.3.1.21 Acid--ammonia (or amine) ligases (amide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylglycinamide formyltransferase 2 activity Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate.
phosphoribosylglycinamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTRIGTPLSP TATRVLLCGC GELGKEVVIE LQRLGVEVIA VDRYANAPAM QVAHRSHVVN
70 80 90 100 110 120
MLDGVALRAV IEAEKPHYIV PEIEAIATAT LVELENEGFT VVPTARATQL TMNREGIRRL
130 140 150 160 170 180
AAEELDLPTS PYHFADTYED YAKAVADLGY PCVVKPVMSS SGKGQSLLRS DADLQKSWDY
190 200 210 220 230 240
AQEGGRAGKG RVIVEGFIDF EYEITLLTVR HVGGTTFLEP VGHRQEKGDY QESWQPQAMS
250 260 270 280 290 300
PKALAESQRV AKAVTDALGG RGLFGVELFV KGDQVWFSEV SPRPHDTGLV TLISQDLSQF
310 320 330 340 350 360
ALHARAILGL PIPVVRQFGP SASAVILPEG QSQQTSFANL GAALSEPDTA IRLFGKPEIN
370 380 390
GTRRMGVCLA RDESVELARA KATRASQAVK VEF