Q87L05

PR
Gene name
mutL
Protein name
DNA mismatch repair protein MutL
Names
Species
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
KEGG Pathway
vpa:VP2819
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-167 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q87L05

Entry ID Method Resolution Chain Position Source
AF-Q87L05-F1 Predicted AlphaFoldDB

No variants for Q87L05

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q87L05

No associated diseases with Q87L05

3 regional properties for Q87L05

Type Name Position InterPro Accession
domain DNA mismatch repair protein, S5 domain 2-like 209 - 355 IPR013507
conserved_site DNA mismatch repair, conserved site 94 - 100 IPR014762
domain MutL, C-terminal, dimerisation 461 - 604 IPR014790

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mismatch repair complex Any complex formed of proteins that act in mismatch repair.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIKILPARL ANQIAAGEVV ERPASVIKEL VENSLDSGAT RIDIDIEKGG AKLIRVRDNG
70 80 90 100 110 120
KGIAKDELGL ALSRHATSKI HTLDDLEAIM SLGFRGEALA SISSVSRLTL TSRPAAQEEA
130 140 150 160 170 180
WSAYSEGRDM QVKLQPAAHP IGTTVEVLDL FFNTPARRKF LRTEKTEFAH IDELLKRIAL
190 200 210 220 230 240
SRFDVSINVR HNGKVIRQYR AAKNQLQTEK RIAAVCGNAF VRNMLRIELE HQGLKLHGWI
250 260 270 280 290 300
TTPDGARQQS DLQYCYVNGR MMRDKLINHA IRQSYEMSLK PDQFAAYVLF IELDPHQVDV
310 320 330 340 350 360
NVHPAKHEVR FHQARLVHDF IYQALADALA QSSVIDKPQV NESAFHRAEP EERESQPETT
370 380 390 400 410 420
PQYSPQSVST TVPERVYQAI DKTPTYPGRT DYEIKPRDRA PSDSSVREAR IADSFKRTDW
430 440 450 460 470 480
IESKLAPKPN VGKERHAEPA PSKREVHAYH ELLKTPDFES QQAEQPTSIE SVREVSLPQV
490 500 510 520 530 540
TALGKALVVV DEQFVLMSSD SGVALVSLPR SEFYRTKGQL TPSEGALKAQ PLLVPLSMKL
550 560 570 580 590 600
DTDLVRLAQD YQQDFAQLGI QLKARNDKAL MVMGVPAPLR QQNLQNLVPD LLSYAQTWMK
610 620 630 640 650 660
GEKASTQMLP ALIDWLAVQV TTVKSHYTLS EAIQIIAELE QLRHGQLPLD DKTFVSAVDF
SATIAKLKP