Q874C1
Gene name |
tim50 (NCU02943) |
Protein name |
Mitochondrial import inner membrane translocase subunit tim50 |
Names |
|
Species |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
KEGG Pathway |
ncr:NCU02943 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q874C1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q874C1-F1 | Predicted | AlphaFoldDB |
No variants for Q874C1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q874C1 | |||||
No associated diseases with Q874C1
16 regional properties for Q874C1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| ptm | EGF-type aspartate/asparagine hydroxylation site | 595 - 606 | IPR000152-1 |
| ptm | EGF-type aspartate/asparagine hydroxylation site | 750 - 761 | IPR000152-2 |
| domain | EGF-like domain | 579 - 620 | IPR000742-1 |
| domain | EGF-like domain | 738 - 775 | IPR000742-2 |
| domain | CUB domain | 354 - 466 | IPR000859-1 |
| domain | CUB domain | 467 - 579 | IPR000859-2 |
| domain | CUB domain | 623 - 735 | IPR000859-3 |
| domain | CUB domain | 779 - 891 | IPR000859-4 |
| domain | CUB domain | 892 - 1008 | IPR000859-5 |
| domain | Peptidase M12A | 153 - 352 | IPR001506 |
| domain | EGF-like calcium-binding domain | 579 - 620 | IPR001881-1 |
| domain | EGF-like calcium-binding domain | 735 - 775 | IPR001881-2 |
| domain | Peptidase, metallopeptidase | 158 - 300 | IPR006026 |
| conserved_site | EGF-like calcium-binding, conserved site | 579 - 604 | IPR018097-1 |
| conserved_site | EGF-like calcium-binding, conserved site | 735 - 759 | IPR018097-2 |
| domain | Tolloid/BMP1 peptidase domain | 153 - 352 | IPR034036 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| TIM23 mitochondrial import inner membrane translocase complex | The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein import into mitochondrial matrix | The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMLSRAAVRS | IAGARVAAHA | ASPLLSQRTL | PAVWTRSMAK | DNKPPKFSKP | ESTPAQKATP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KAPEPAESEK | AEQKQQQQQQ | QQTPAESEPE | PEIDLSKLPD | LRGGIPTTLE | YEMAQKEAGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPVAGEEAET | QAEGAEGPEA | ATSGSGGGGR | KKGQLPDSAY | VSSTEKRRQK | MANWAFIAAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LALVGGTIYL | GREWDEEELE | KHHDIPNGWG | LGLWWKRAKA | RMTGTVSYYQ | EPAFEKLLPD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PDPSFERPYT | LCISLEDMLV | HSEWTRDHGW | RLAKRPGVDY | FLRYLSQYYE | IVLFTSVPFA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NAEPIVRKMD | PYRFIMWPLF | REATKYKDGE | IVKDLSYLNR | DLSKVIIIDT | DPKHVRAQPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NAIVLPKWKG | DPKDTELVSL | VPFLEFIHTM | NFPDVRKVLK | SFEGQHIPTE | FARREAIARA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EHNKLVAAKA | KKAGLGSLGA | RFGIKPSKLN | PMAMEGEEDP | SEAFAKGKMI | QDIARERGMR |
| 490 | 500 | 510 | 520 | 530 | |
| NYLAMEEEIK | KNGEMWLKME | QEAQEKAQKE | MMKNMQSSVF | GWFGGAPSGE | QQSGESEKKA |