AiPD: Autoinhibited Protein Database

Q86W54

Gene name	SPATA24
Protein name	Spermatogenesis-associated protein 24
Names	Testis protein T6441 homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:202051
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-205 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

30-205 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86W54

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86W54-F1	Predicted				AlphaFoldDB

141 variants for Q86W54

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1452461610 CA361167127	2	A>V		No	ClinGen TOPMed
CA361167113 rs1488201240	4	P>L		No	ClinGen gnomAD
CA3434806 rs772689742	6	G>R		No	ClinGen ExAC gnomAD
CA128261327 rs746625944	7	W>*		No	ClinGen TOPMed gnomAD
CA361167095 rs746625944	7	W>C		No	ClinGen TOPMed gnomAD
rs1038573784 CA128261322	8	S>P		No	ClinGen Ensembl
CA3434805 rs760057919	9	K>E		No	ClinGen ExAC gnomAD
CA361167088 rs760057919	9	K>Q		No	ClinGen ExAC gnomAD
rs939795210 CA128261317	10	A>S		No	ClinGen TOPMed gnomAD
CA361167081 rs939795210	10	A>T		No	ClinGen TOPMed gnomAD
CA361167077 rs1234186593	10	A>V		No	ClinGen gnomAD
CA361167068 rs1581406126	12	S>A		No	ClinGen Ensembl
rs774861309 CA3434804	13	G>V		No	ClinGen ExAC gnomAD
rs1339672353 CA361167055	14	S>C		No	ClinGen gnomAD
rs1339672353 CA361167054	14	S>F		No	ClinGen gnomAD
CA361167058 rs1397902673	14	S>P		No	ClinGen gnomAD
rs1399381768 CA361167049	15	V>G		No	ClinGen gnomAD
rs201105749 CA361167053	15	V>L		No	ClinGen ExAC TOPMed gnomAD
rs201105749 CA3434803	15	V>M		No	ClinGen ExAC TOPMed gnomAD
CA361167045 rs1171486205	16	C>Y		No	ClinGen gnomAD
CA361167040 rs1165410700	17	L>F		No	ClinGen TOPMed
CA361167034 rs1466176463	18	A>T		No	ClinGen gnomAD
CA361167021 rs1473030477	20	D>Y		No	ClinGen Ensembl
CA361167012 rs1430957586	21	Q>E		No	ClinGen gnomAD
rs1300668060 CA361166999	23	R>W		No	ClinGen TOPMed
CA361166989 rs1417329813	24	D>E		No	ClinGen TOPMed gnomAD
CA361166977 rs1168177779	26	I>T		No	ClinGen TOPMed gnomAD
rs62385295 CA128261267	28	S>F		No	ClinGen TOPMed
rs749492678 CA3434802	28	S>T		No	ClinGen ExAC gnomAD
rs62385295 CA361166964	28	S>Y		No	ClinGen TOPMed
CA128261263 rs997174973	29	Q>*		No	ClinGen TOPMed
rs778032308 CA3434801	31	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1489326402 CA361166940	32	L>I		No	ClinGen TOPMed
CA361166936 rs1195895027	32	L>Q		No	ClinGen gnomAD
rs1194524886 CA361166914	35	Q>H		No	ClinGen TOPMed
rs1261612571 CA804607327	36	L>R		No	ClinGen TOPMed
rs1441225530 CA361166911	36	L>V		No	ClinGen gnomAD
CA361166905 rs1255478548	37	R>K		No	ClinGen TOPMed gnomAD
rs1369409999 CA361166890	39	V>L		No	ClinGen TOPMed
CA361166867 rs1235499008	41	V>I		No	ClinGen gnomAD
rs1010640719 CA128260589	43	Q>*		No	ClinGen gnomAD
CA3434794 rs758166212 CA3434795	44	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1030628263 CA128260579	45	E>*		No	ClinGen TOPMed gnomAD
CA361166842 rs1030628263 COSM3238028 COSM3826866	45	E>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs977480595 CA128260577	49	S>G		No	ClinGen TOPMed gnomAD
CA361166810 rs1216091297	49	S>T		No	ClinGen TOPMed gnomAD
TCGA novel	53	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3696936 COSM3696937 CA361166781 rs1352199315	53	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs767134559 CA128260540	54	Q>H		No	ClinGen gnomAD
rs192704505 CA3434793	55	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1561993744 CA361166762	56	V>M		No	ClinGen Ensembl
rs1384300682 CA361166740	59	K>Q		No	ClinGen TOPMed gnomAD
rs770045128 CA361166682	62	E>*		No	ClinGen ExAC gnomAD
rs770045128 CA3434783	62	E>K		No	ClinGen ExAC gnomAD
rs1280899506 CA361166647	65	A>S		No	ClinGen gnomAD
CA361166641 rs1433916932	66	A>T		No	ClinGen gnomAD
rs1304496375 CA361166626	67	H>R		No	ClinGen TOPMed
CA128260312 rs867210031	68	A>T		No	ClinGen TOPMed
CA3434781 rs541311172	71	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs970401726 CA128260307	71	K>T		No	ClinGen Ensembl
rs1427037023 CA361166585	72	V>I		No	ClinGen gnomAD
rs1321280653 CA361166568	74	L>M		No	ClinGen TOPMed
CA128260305 rs745716164	75	A>V		No	ClinGen gnomAD
CA128260303 rs949999953	78	E>G		No	ClinGen TOPMed gnomAD
CA361166519 rs1158640429	79	E>G		No	ClinGen gnomAD
CA3434780 rs768685286	79	E>K		No	ClinGen ExAC
rs895760140 CA128260282	80	K>N		No	ClinGen TOPMed
CA361166467 rs1401325072	84	A>P		No	ClinGen gnomAD
COSM3365855 CA361166447 COSM3365856 rs1189642714	86	G>R	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1012454922 CA128260258	87	E>K		No	ClinGen Ensembl
CA128260243 rs959615179	88	V>I		No	ClinGen Ensembl
CA3434778 rs758192079	90	V>L		No	ClinGen ExAC gnomAD
CA3434777 rs758192079	90	V>M		No	ClinGen ExAC gnomAD
rs1280827784 CA361166393	91	L>V		No	ClinGen TOPMed gnomAD
rs1006365526 CA128260236	99	K>E		No	ClinGen TOPMed
CA3434776 rs369306056	99	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs886585824 CA128260230	104	K>E		No	ClinGen Ensembl
rs200067820 CA361166225	105	A>G		No	ClinGen ExAC TOPMed gnomAD
CA361166228 rs1283794665	105	A>T		No	ClinGen gnomAD
rs200067820 CA3434775	105	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3434766 rs765454016	106	L>F		No	ClinGen ExAC TOPMed gnomAD
CA361166213 rs765454016	106	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1441404486 CA361166200	108	S>R		No	ClinGen gnomAD
CA361166194 rs1263341226	109	V>L		No	ClinGen gnomAD
rs1316393884 CA361166144	116	E>*		No	ClinGen TOPMed gnomAD
TCGA novel	118	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA361166124 rs1277998229	118	S>R		No	ClinGen TOPMed gnomAD
rs369759443 CA128260135	121	D>E		No	ClinGen gnomAD
CA128260122 rs977851437	122	Q>R		No	ClinGen Ensembl
rs985411152 CA128260120	127	C>G		No	ClinGen TOPMed gnomAD
CA361166065 rs985411152	127	C>S		No	ClinGen TOPMed gnomAD
CA361166058 rs1301666157	128	N>H		No	ClinGen TOPMed gnomAD
CA361166055 rs1214056455	128	N>S		No	ClinGen TOPMed gnomAD
rs1454973919 CA361165656	129	E>D		No	ClinGen gnomAD
CA361165652 rs1375563765	130	I>F		No	ClinGen gnomAD
CA3434743 rs772001572	131	E>G		No	ClinGen ExAC gnomAD
CA128257641 rs1022211411	131	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs956527936 CA128257632	133	H>Y		No	ClinGen TOPMed gnomAD
rs745839774 CA3434742	138	E>K		No	ClinGen ExAC gnomAD
CA3434741 rs774134135	140	I>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	140	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA128257627 rs774134135	140	I>T		No	ClinGen ExAC TOPMed gnomAD
rs370084329 CA3434740	141	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA361165570 rs1313479026	142	N>S		No	ClinGen TOPMed
TCGA novel	145	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	148	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA128257603 rs1031482130	152	Q>E		No	ClinGen TOPMed
rs1262714653 CA361165487	153	Q>P		No	ClinGen gnomAD
rs138900287 CA3434737	154	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA361165474 rs1323931413	155	I>N		No	ClinGen gnomAD
CA361165473 rs1323931413	155	I>T		No	ClinGen gnomAD
rs1284994655 CA361165462	156	S>N		No	ClinGen gnomAD
rs907022219 CA128257594	157	Q>P		No	ClinGen TOPMed gnomAD
rs755846563 CA3434735	161	I>F		No	ClinGen ExAC gnomAD
CA361165109 rs1379886229	165	H>P		No	ClinGen TOPMed gnomAD
rs1379886229 CA361165107	165	H>R		No	ClinGen TOPMed gnomAD
rs921441422 CA128257515	166	M>I		No	ClinGen Ensembl
TCGA novel	166	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA128257509 rs1039277245	169	F>C		No	ClinGen TOPMed
rs975907566 CA128257491	170	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1156798885 CA361165002	170	R>W		No	ClinGen TOPMed
CA361164986 rs1414829340	171	I>F		No	ClinGen TOPMed
CA361164945 rs1407826322	173	K>E		No	ClinGen gnomAD
rs1177048619 CA361164919	174	Q>*		No	ClinGen TOPMed
rs1409718346 CA361164905	174	Q>H		No	ClinGen gnomAD
rs10900862 CA361164863	176	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs754212440 CA3434728	179	M>I		No	ClinGen ExAC
rs183526939 CA3434726	185	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs183526939 CA3434727	185	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA128257468 rs928726483	185	Q>R		No	ClinGen TOPMed
CA128257463 rs540288040	187	H>R		No	ClinGen gnomAD
rs369824194 CA361164696	194	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs369824194 CA128257450	194	R>G		No	ClinGen TOPMed gnomAD
CA3434724 rs767683626	194	R>H		No	ClinGen ExAC TOPMed gnomAD
rs963364133 CA128257427	197	R>C		No	ClinGen TOPMed gnomAD
rs1197410950 COSM3946885 CA361164671	197	R>H	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA361164670 rs1197410950	197	R>P		No	ClinGen gnomAD
CA361164654 rs1561991400	199	H>Y		No	ClinGen Ensembl
rs558345523 CA3434722	201	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1032033916 CA128257422	204	E>K		No	ClinGen TOPMed gnomAD
rs1248450595 CA361164592	206	K>L		No	ClinGen TOPMed

No associated diseases with Q86W54

No regional properties for Q86W54

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q86W54

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus, nucleolus Nucleus, nucleoplasm	Associated with chromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
male germ cell nucleus	The nucleus of a male germ cell, a reproductive cell in males.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
identical protein binding	Binding to an identical protein or proteins.

2 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MATPLGWSKA	GSGSVCLALD	QLRDVIESQE	ELIHQLRNVM	VLQDENFVSK	EEFQAVEKKL
70	80	90	100	110	120
VEEKAAHAKT	KVLLAKEEEK	LQFALGEVEV	LSKQLEKEKL	AFEKALSSVK	SKVLQESSKK
130	140	150	160	170	180
DQLITKCNEI	ESHIIKQEDI	LNGKENEIKE	LQQVISQQKQ	IFRNHMSDFR	IQKQQESYMA
190	200
QVLDQKHKKA	SGTRQARSHQ	HPREK