AiPD: Autoinhibited Protein Database

Q86VD7

Gene name	SLC25A42
Protein name	Mitochondrial coenzyme A transporter SLC25A42
Names	Solute carrier family 25 member 42
Species	Homo sapiens (Human)
KEGG Pathway	hsa:284439
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-74 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86VD7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86VD7-F1	Predicted				AlphaFoldDB

224 variants for Q86VD7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs864321624 RCV000412490 VAR_082152 RCV000203566 CA279953 RCV000984915	291	N>D	SLC25A42-related mitochondrial disorder Metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression Inborn mitochondrial myopathy MECREN; loss-of-function variant unable to rescue motor deficiencies in zebrafish morphants [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
CA9321312 rs377407327	3	N>S		No	ClinGen ESP ExAC gnomAD
CA404886646 rs1289006703	7	E>D		No	ClinGen gnomAD
rs1449812385 CA404886652	8	G>C		No	ClinGen gnomAD
rs1223416165 CA404886669	8	G>D		No	ClinGen gnomAD
rs1449812385 CA404886656	8	G>S		No	ClinGen gnomAD
rs117940121 CA9321313	9	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404886710 rs117940121	9	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773838795 CA9321315	10	V>L		No	ClinGen ExAC gnomAD
CA306285630 rs996227499	11	R>*		No	ClinGen TOPMed gnomAD
CA9321316 rs761258835	11	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9321317 rs767022538	13	H>P		No	ClinGen ExAC gnomAD
CA9321318 rs571380861	15	D>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs756604951 CA9321320	15	D>E		No	ClinGen ExAC gnomAD
CA9321322 rs755219312	17	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs1344961227 CA404886879	18	A>S		No	ClinGen gnomAD
rs748394350 CA9321324	22	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9321328 rs745768284	24	V>F		No	ClinGen ExAC TOPMed gnomAD
CA9321327 rs745768284	24	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA306285656 rs12983184	26	S>*		No	ClinGen Ensembl
CA9321330 rs749095738	27	K>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771749461 CA9321361	28	R>C		No	ClinGen ExAC TOPMed gnomAD
rs771749461 CA404888798	28	R>G		No	ClinGen ExAC TOPMed gnomAD
rs112742931 CA9321362	28	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA306287442 rs1052694166	34	L>P		No	ClinGen TOPMed
CA9321364 rs770485122	35	S>G		No	ClinGen ExAC gnomAD
rs1022873578 CA306287452	36	S>F		No	ClinGen gnomAD
rs765645817 CA9321368	37	L>P		No	ClinGen ExAC gnomAD
rs138517933 CA9321367	37	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs17854359 CA306287463 VAR_032970	39	S>P		No	ClinGen UniProt Ensembl dbSNP
CA306287466 rs369633428	40	G>A		No	ClinGen ESP TOPMed
CA404888966 rs1568521782	41	A>V		No	ClinGen Ensembl
rs1253839907 CA404888973	42	L>P		No	ClinGen gnomAD
CA404888983 rs1346706156	43	A>G		No	ClinGen gnomAD
rs535457015 CA306287468	49	T>I		No	ClinGen Ensembl
CA9321370 rs763264125	50	A>V		No	ClinGen ExAC gnomAD
TCGA novel	53	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	59	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404889312 rs1184944921	60	I>V		No	ClinGen gnomAD
CA306288296 rs947589044	65	S>A		No	ClinGen TOPMed gnomAD
CA9321416 rs758381313	75	R>Q		No	ClinGen ExAC
rs1599689695 CA404891562	78	Y>S		No	ClinGen Ensembl
CA9321418 rs372578398	79	Y>C		No	ClinGen ESP ExAC gnomAD
TCGA novel	80	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1599689702 CA404891689	80	T>P		No	ClinGen Ensembl
CA306288470 rs752702761 CA306288472	83	N>K		No	ClinGen ExAC TOPMed gnomAD
CA9321421 rs745521216	88	S>T		No	ClinGen ExAC
rs1276311844 CA404892347	97	M>I		No	ClinGen gnomAD
rs1409744970 CA404892337	97	M>V		No	ClinGen gnomAD
rs138036287 CA9321427	100	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000735224 rs1568523935 CA404892453	103	Y>*		No	ClinGen ClinVar Ensembl dbSNP
CA9321428 rs772332647	104	A>G		No	ClinGen ExAC TOPMed gnomAD
CA404892456 rs1218472304	104	A>T		No	ClinGen gnomAD
CA9321429 rs531748523	105	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA306288486 rs960278892	106	I>V		No	ClinGen TOPMed gnomAD
rs760915278 CA404892533	107	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA306288493 rs916048583	110	A>T		No	ClinGen TOPMed
rs776738600 CA9321432	110	A>V		No	ClinGen ExAC TOPMed gnomAD
CA9321434 rs764158605	112	E>D		No	ClinGen ExAC gnomAD
rs762767863 CA9321433	112	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9321435 rs751466309	113	E>*		No	ClinGen ExAC TOPMed gnomAD
rs751466309 CA404892682	113	E>K		No	ClinGen ExAC TOPMed gnomAD
rs751466309 CA9321436	113	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1423955807 CA404892710	114	Y>H		No	ClinGen gnomAD
rs767453952 CA9321437	115	K>R		No	ClinGen ExAC gnomAD
CA9321439 rs755883383	116	R>C		No	ClinGen ExAC gnomAD
CA404892772 rs1428594464	116	R>H		No	ClinGen gnomAD
CA404892774 rs1428594464	116	R>L		No	ClinGen gnomAD
CA404892765 rs755883383	116	R>S		No	ClinGen ExAC gnomAD
rs779681889 CA9321440	117	I>V		No	ClinGen ExAC gnomAD
CA9321442 rs141712568	119	G>A		No	ClinGen ESP ExAC gnomAD
CA9321443 rs141712568	119	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs772439531 CA9321445	120	S>N		No	ClinGen ExAC TOPMed gnomAD
CA9321444 rs748604140	120	S>R		No	ClinGen ExAC TOPMed gnomAD
rs778129613 CA9321446	122	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1226313827 CA404893001	124	F>V		No	ClinGen gnomAD
CA9321448 rs771181259	125	R>H		No	ClinGen ExAC TOPMed gnomAD
CA404893055 rs766495888	126	G>E		No	ClinGen gnomAD
CA306288537 rs766495888	126	G>V		No	ClinGen gnomAD
rs1447440705 CA404893210	128	A>S		No	ClinGen gnomAD
rs199634097 CA9321472	131	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs950963322 CA306288861	131	P>L		No	ClinGen TOPMed
rs10421670 CA306288863	132	W>R		No	ClinGen Ensembl
rs772204985 CA9321474	133	P>L		No	ClinGen ExAC gnomAD
CA9321473 rs748090374	133	P>S		No	ClinGen ExAC gnomAD
TCGA novel	134	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404893414 rs1236169194	138	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs776302265 CA9321478	139	A>S		No	ClinGen ExAC gnomAD
CA9321479 rs776302265	139	A>T		No	ClinGen ExAC gnomAD
rs1599690689 CA404893483	140	L>R		No	ClinGen Ensembl
CA404893494 rs1599690694	141	A>V		No	ClinGen Ensembl
rs758900040 CA404893526	143	T>K		No	ClinGen ExAC TOPMed gnomAD
rs758900040 CA9321483	143	T>M		No	ClinGen ExAC TOPMed gnomAD
rs764642274 CA9321484	144	T>P		No	ClinGen ExAC gnomAD
rs752073615 CA9321485	146	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9321486 rs757578000	148	L>V		No	ClinGen ExAC gnomAD
rs1293888469 CA404893706	151	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs781433451 CA9321487	151	P>S		No	ClinGen ExAC gnomAD
TCGA novel	153	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1173741072 CA404893841	157	A>S		No	ClinGen TOPMed
CA404893884 rs1275885523	160	A>T		No	ClinGen gnomAD
CA9321493 rs773221554	161	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9321494 rs746971555	163	P>L		No	ClinGen ExAC gnomAD
CA9321520 rs773892280	167	Y>D		No	ClinGen ExAC gnomAD
CA9321522 rs767968883	169	N>S		No	ClinGen ExAC gnomAD
CA404895098 rs1208457977	170	I>M		No	ClinGen gnomAD
CA9321523 rs372172962	171	F>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs149585119 CA9321524 COSM4140426	176	R>C	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA9321525 rs766802370	176	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA404895280 COSM1391779 rs1323880492	178	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA404895282 rs1323880492	178	S>W		No	ClinGen TOPMed
CA9321528 rs779102013	179	R>G		No	ClinGen ExAC gnomAD
rs980923440 CA306289606	180	E>A		No	ClinGen Ensembl
CA9321529 rs373877778	180	E>K		No	ClinGen ESP ExAC gnomAD
rs1341318042 CA404895349	182	G>R		No	ClinGen TOPMed
TCGA novel	183	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9321532 rs745821632	184	K>N		No	ClinGen ExAC gnomAD
CA404895529 rs1383451180	189	G>R		No	ClinGen gnomAD
rs1296866032 CA404895593	191	M>L		No	ClinGen gnomAD
CA9321535 rs779873546	191	M>T		No	ClinGen ExAC gnomAD
rs144256360 CA404895633	192	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9321536 rs144256360	192	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404895684 rs773840865	194	V>L		No	ClinGen ExAC gnomAD
rs773840865 CA9321538	194	V>M		No	ClinGen ExAC gnomAD
rs761173709 CA9321539	198	I>L		No	ClinGen ExAC gnomAD
rs140711318 CA9321540	199	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs372199103 CA306289648	199	P>L		No	ClinGen ESP TOPMed gnomAD
rs925587101 CA306289655	201	A>G		No	ClinGen TOPMed
rs531577760 CA306289652	201	A>T		No	ClinGen TOPMed
TCGA novel	202	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	205	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs946741937 CA306289657	207	T>I		No	ClinGen Ensembl
rs1599692607 CA404896011	208	Y>S		No	ClinGen Ensembl
CA306289668 rs866770230	209	E>*		No	ClinGen Ensembl
CA9321544 rs546562344	210	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765611053 CA9321546	211	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	211	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs921374052 CA306289701	215	H>R		No	ClinGen TOPMed
rs45546936 CA9321547	216	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1568527029 CA404897337	218	Y>F		No	ClinGen Ensembl
rs1055727120 CA306290683	219	S>G		No	ClinGen TOPMed gnomAD
CA404897360 rs1376066628	219	S>R		No	ClinGen gnomAD
rs771630381 CA9321560	221	R>H		No	ClinGen ExAC TOPMed gnomAD
CA404897398 rs1239069686	222	R>P		No	ClinGen Ensembl
rs777120256 CA9321561	222	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1236616644 CA404897444	225	Y>C		No	ClinGen gnomAD
CA404897461 rs759920889	226	P>L		No	ClinGen ExAC TOPMed gnomAD
rs759920889 CA9321562	226	P>R		No	ClinGen ExAC TOPMed gnomAD
CA404897457 rs1282312225	226	P>S		No	ClinGen gnomAD
rs1230952932 CA404897484	227	F>L		No	ClinGen TOPMed gnomAD
rs895873119 CA306290698	228	E>K		No	ClinGen TOPMed gnomAD
CA404897488 rs895873119	228	E>Q		No	ClinGen TOPMed gnomAD
rs1249360443 CA404897516	229	R>L		No	ClinGen TOPMed gnomAD
CA404897513 rs1249360443	229	R>P		No	ClinGen TOPMed gnomAD
CA404897502 rs1177389428	229	R>S		No	ClinGen gnomAD
rs1266266431 CA404897546	231	I>T		No	ClinGen gnomAD
CA306290707 rs1042233979	235	C>F		No	ClinGen Ensembl
rs950156951 CA306290702	235	C>G		No	ClinGen TOPMed gnomAD
rs1174987439 CA404897616	235	C>W		No	ClinGen gnomAD
CA404897619 rs1162718866	236	A>T		No	ClinGen TOPMed
rs1442899779 CA404897747	237	G>S		No	ClinGen TOPMed
CA404897779 rs1179520685	238	L>F		No	ClinGen TOPMed
CA404897810 rs775814532	239	I>M		No	ClinGen ExAC TOPMed gnomAD
CA404897801 rs1169384229	239	I>V		No	ClinGen gnomAD
rs1356610610 CA404897828	240	G>V		No	ClinGen gnomAD
rs1224324207 CA404897830	241	Q>E		No	ClinGen TOPMed
CA9321565 rs763284891	242	S>L		No	ClinGen ExAC gnomAD
rs751729984 CA9321567	244	S>W		No	ClinGen ExAC gnomAD
CA404897860 rs1467434357	245	Y>H		No	ClinGen TOPMed gnomAD
CA404897871 rs1213894287	246	P>R		No	ClinGen TOPMed gnomAD
CA404897867 rs1341622062	246	P>S		No	ClinGen gnomAD
rs1270839683 CA404897883	248	D>V		No	ClinGen gnomAD
rs752146829 CA9321568	249	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1375781278 CA404897891	250	V>M		No	ClinGen TOPMed
CA404897903 rs1466860714	252	R>W		No	ClinGen gnomAD
CA404897960 rs778705985	261	G>R		No	ClinGen ExAC TOPMed gnomAD
CA9321572 rs778705985	261	G>S		No	ClinGen ExAC TOPMed gnomAD
CA306290761 rs375217405	262	Y>N		No	ClinGen TOPMed
rs1322574500 CA404897976	263	P>R		No	ClinGen gnomAD
CA9321574 rs533458331	265	A>T		No	ClinGen 1000Genomes ExAC
CA404897996 rs1164528950	267	I>V		No	ClinGen gnomAD
CA9321576 rs746585668	268	A>S		No	ClinGen ExAC TOPMed gnomAD
rs746585668 CA404898003	268	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs202000540 CA9321577	269	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1018628231 CA306290775	269	R>H		No	ClinGen TOPMed gnomAD
CA404898012 rs1364502145	270	T>A		No	ClinGen gnomAD
CA306290780 rs370533233	270	T>K		No	ClinGen ESP TOPMed gnomAD
CA404898023 rs1406128986	272	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA306290784 rs1020157107	274	I>V		No	ClinGen TOPMed
CA404898039 rs1246592621	275	V>M		No	ClinGen TOPMed
rs200692918 CA404898048	276	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs200692918 CA404898047	276	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs200692918 CA9321578	276	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1272312180 CA404898053	277	E>G		No	ClinGen gnomAD
CA404898049 rs1214871623	277	E>K		No	ClinGen gnomAD
TCGA novel	279	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs560478326 CA9321580	281	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA404898085 rs1213053769	282	R>H		No	ClinGen gnomAD
rs1287540218 CA404898082	282	R>S		No	ClinGen TOPMed
CA9321582 rs763081314	283	G>A		No	ClinGen ExAC gnomAD
rs1281755886 CA404898093	284	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1187948506 CA404898110	286	K>R		No	ClinGen gnomAD
TCGA novel	287	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA306290816 COSM460014 rs764432730	288	L>F	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA404898125 rs1220702211	288	L>W		No	ClinGen TOPMed
CA9321585 rs761812479	290	M>V		No	ClinGen ExAC gnomAD
rs1388204344 CA404898171	293	V>F		No	ClinGen gnomAD
rs1320371846 CA404898182	294	K>E		No	ClinGen gnomAD
rs1320371846 CA404898180	294	K>Q		No	ClinGen gnomAD
rs1599695310 CA404898198	295	G>V		No	ClinGen Ensembl
CA404898225 rs1403029465	298	A>T		No	ClinGen TOPMed
TCGA novel	301	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404898271 rs1431371391	302	S>C		No	ClinGen gnomAD
rs140099041 CA9321589	304	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1234931232 CA404898365	310	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9321591 rs757977417	311	I>M		No	ClinGen ExAC gnomAD
CA9321590 rs752608316	311	I>N		No	ClinGen ExAC TOPMed gnomAD
rs17854358 CA306290831 VAR_032971	312	L>M		No	ClinGen UniProt Ensembl dbSNP
rs529307843 CA9321592	314	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs529307843 CA404898409	314	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	314	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9321593 rs781548124	315	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1415349573 CA404898423	315	H>R		No	ClinGen TOPMed
TCGA novel	316	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

1 associated diseases with Q86VD7

[MIM: 618416]: Metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression (MECREN)

An autosomal recessive disease characterized by muscle weakness, developmental delay, lactic acidosis, and encephalopathy. The severity of the clinical manifestations is highly variable even within affected individuals of the same family, ranging from asymptomatic lactic acidosis to severe developmental regression, epilepsy, intellectual disability, metabolic crisis, and multiorgan involvement. {ECO:0000269|PubMed:26541337, ECO:0000269|PubMed:29327420, ECO:0000269|PubMed:29923093, ECO:0000269|PubMed:30237576}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

An autosomal recessive disease characterized by muscle weakness, developmental delay, lactic acidosis, and encephalopathy. The severity of the clinical manifestations is highly variable even within affected individuals of the same family, ranging from asymptomatic lactic acidosis to severe developmental regression, epilepsy, intellectual disability, metabolic crisis, and multiorgan involvement. {ECO:0000269|PubMed:26541337, ECO:0000269|PubMed:29327420, ECO:0000269|PubMed:29923093, ECO:0000269|PubMed:30237576}. Note=The disease is caused by variants affecting the gene represented in this entry.

4 regional properties for Q86VD7

Type	Name	Position	InterPro Accession
conserved_site	DNA mismatch repair, conserved site	123 - 129	IPR014762
repeat	Mitochondrial substrate/solute carrier	31 - 119	IPR018108-1
repeat	Mitochondrial substrate/solute carrier	129 - 216	IPR018108-2
repeat	Mitochondrial substrate/solute carrier	224 - 313	IPR018108-3

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
ADP phosphatase activity	Catalysis of the reaction: ADP + H2O = AMP + phosphate.
ADP transmembrane transporter activity	Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other.
AMP transmembrane transporter activity	Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other.
ATP transmembrane transporter activity	Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other.
coenzyme A transmembrane transporter activity	Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.

4 GO annotations of biological process

Name	Definition
ADP transport	The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
AMP transport	The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
ATP transport	The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
coenzyme A transmembrane transport	The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8WUT9	SLC25A43	Solute carrier family 25 member 43	Homo sapiens (Human)	PR
Q0P483	slc25a42	Mitochondrial coenzyme A transporter SLC25A42	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MGNGVKEGPV	RLHEDAEAVL	SSSVSSKRDH	RQVLSSLLSG	ALAGALAKTA	VAPLDRTKII
70	80	90	100	110	120
FQVSSKRFSA	KEAFRVLYYT	YLNEGFLSLW	RGNSATMVRV	VPYAAIQFSA	HEEYKRILGS
130	140	150	160	170	180
YYGFRGEALP	PWPRLFAGAL	AGTTAASLTY	PLDLVRARMA	VTPKEMYSNI	FHVFIRISRE
190	200	210	220	230	240
EGLKTLYHGF	MPTVLGVIPY	AGLSFFTYET	LKSLHREYSG	RRQPYPFERM	IFGACAGLIG
250	260	270	280	290	300
QSASYPLDVV	RRRMQTAGVT	GYPRASIART	LRTIVREEGA	VRGLYKGLSM	NWVKGPIAVG
310
ISFTTFDLMQ	ILLRHLQS